Document Detail


JNK signalling controls remodelling of the segment boundary through cell reprogramming during Drosophila morphogenesis.
MedLine Citation:
PMID:  20543996     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Segments are fundamental units in animal development which are made of distinct cell lineages separated by boundaries. Although boundaries show limited plasticity during their formation for sharpening, cell lineages make compartments that become tightly restricted as development goes on. Here, we characterize a unique case of breaking of the segment boundary in late drosophila embryos. During dorsal closure, specific cells from anterior compartments cross the segment boundary and enter the adjacent posterior compartments. This cell mixing behaviour is driven by an anterior-to-posterior reprogramming mechanism involving de novo expression of the homeodomain protein Engrailed. Mixing is accompanied by stereotyped local cell intercalation, converting the segment boundary into a relaxation compartment important for tension-release during morphogenesis. This process of lineage switching and cell remodelling is controlled by JNK signalling. Our results reveal plasticity of segment boundaries during late morphogenesis and a role for JNK-dependent developmental reprogramming in this process.
Authors:
Melanie Gettings; Fanny Serman; Raphaël Rousset; Patrizia Bagnerini; Luis Almeida; Stéphane Noselli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-08
Journal Detail:
Title:  PLoS biology     Volume:  8     ISSN:  1545-7885     ISO Abbreviation:  PLoS Biol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-10-21     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101183755     Medline TA:  PLoS Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e1000390     Citation Subset:  IM    
Affiliation:
Institute of Developmental Biology and Cancer, University of Nice, CNRS, Nice, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Drosophila / cytology,  growth & development*
MAP Kinase Kinase 4 / metabolism*
Morphogenesis*
Signal Transduction*
Chemical
Reg. No./Substance:
EC 2.7.12.2/MAP Kinase Kinase 4
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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