Document Detail


JC virus strains indigenous to northeastern Siberians and Canadian Inuits are unique but evolutionally related to those distributed throughout Europe and Mediterranean areas.
MedLine Citation:
PMID:  12187385     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human polyomavirus JC virus (JCV) isolates around the world are classified into more than 10 geographically distinct genotypes (designated as subtypes). Evolutionary relationships among JCV subtypes were recently examined, and the following pattern of JCV evolution was indicated. The ancestral JCV first divided into three superclusters, designated Types A, B, and C. A split in Type A generated two subtypes, EU-a and -b, containing mainly European and Mediterranean isolates. The split in Type B generated Af 2 (the major African subtype), Bl-c (a minor European subtype), and various Asian subtypes. Type C generated a single subtype (Afl), consisting of isolates derived from western Africa. In this study, JCV isolates prevalent among northeastern Siberians and Canadian Inuits were evaluated in the context of the above-described pattern of JCV evolution. The Siberian/Arctic JCV isolates were classified as belonging mainly to Type A, based on the result of a preliminary phylogenetic analysis. We then examined, using the whole-genome approach, the phylogenetic relationships among worldwide Type A isolates. In neighbor-joining and maximum-likelihood analyses, Type A JCVs worldwide consistently diverged into three subtypes, EU-a, -b, and -c, with high bootstrap probabilities. EU-c was constructed only by northeastern Siberian isolates, derived mainly from Nanais living in the lower Amur River region, and was shown to have been generated by the first split in Type A. Most Siberian/Arctic isolates derived from Chukchis, Koryaks, and Canadian Inuits formed a distinct cluster within the EU-a subtype, with a high bootstrap probability. Based on the present findings, we discuss ancient human migrations, accompanied by Type A JCVs, across Asia and to Arctic areas of North America.
Authors:
Chie Sugimoto; Masami Hasegawa; Huai-Ying Zheng; Vladimir Demenev; Yoshiharu Sekino; Kazuo Kojima; Takeo Honjo; Hiroshi Kida; Tapani Hovi; Timo Vesikari; Jack A Schalken; Kyoichi Tomita; Yukari Mitsunobu; Hiroshi Ikegaya; Nobuyoshi Kobayashi; Tadaichi Kitamura; Yoshiaki Yogo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of molecular evolution     Volume:  55     ISSN:  0022-2844     ISO Abbreviation:  J. Mol. Evol.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-08-20     Completed Date:  2003-02-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0360051     Medline TA:  J Mol Evol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  322-35     Citation Subset:  IM    
Affiliation:
Laboratory of Viral Infection, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Arctic Regions
Canada / ethnology
Emigration and Immigration
Europe
Evolution
Humans
JC Virus / classification*,  isolation & purification,  physiology*
Mediterranean Region / ethnology
Middle Aged
Phylogeny
Polyomavirus Infections / virology
Sequence Analysis, DNA
Siberia / ethnology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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