Document Detail

J.B. Wolffe Memorial Lecture. "Why exercise?".
MedLine Citation:
PMID:  1549003     Owner:  NLM     Status:  MEDLINE    
There is a pronounced plasticity and adaptability in the structural and/or functional properties of cells, tissues, and organ systems in the human body when exposed to various stimuli. While there is unanimous agreement that regular exercise is essential for optimal function of the human body, it is evident that extrinsic factors, such as diet and exercise habits, are reflected in the morbidity and mortality statistics, especially in the aged. Aging is obligatorily associated with reduced maximal aerobic power and reduced muscle strength, i.e., with reduced physical fitness. As a consequence of diminished exercise tolerance, a large and increasing number of elderly persons will be living below, at, or just above "thresholds" of physical ability, needing only a minor intercurrent illness to render them completely dependent. Physical training can readily produce a profound improvement of functions essential for physical fitness in old age. Adaptability to regular physical activity serves to cause less disruption of the cell's "milieu interieur" and minimizes fatigue, thereby enhancing performance and the economy of energy output during exercise.
P O Astrand
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  24     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-04-23     Completed Date:  1992-04-23     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  153-62     Citation Subset:  IM; S    
Department of Physiology III, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
Aging / physiology
Coronary Disease / physiopathology
Exercise / physiology*
Muscles / physiology
Osteoporosis / physiopathology
Oxygen Consumption / physiology
Physical Endurance / physiology
Risk Factors

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