Document Detail

JAK2V617F mutation in patients with thrombosis: to screen or not to screen?
MedLine Citation:
PMID:  21118380     Owner:  NLM     Status:  In-Process    
INTRODUCTION: Thrombotic complications are a main concern in patients with myeloproliferative neoplasms. Recently, a gain-of-function mutation of the gene encoding the JAK2 tyrosine kinase that results in a valine-to-phenylalanine substitution at position 617 (V617F) has been described. Since the description of the JAK2-V617F mutation and its finding in patients with splanchnic vein thrombosis without an overt myeloproliferative neoplasm, many groups have studied the prevalence of this mutation in patients with unexplained venous and arterial thrombosis.
METHODS: A literature search was made using the key words thrombosis, JAK2V617F mutation, myeloproliferative neoplasms, cerebral vein thrombosis and splanchnic vein thrombosis.
RESULTS: JAK2V617F is frequent in patients with splanchnic vein thrombosis, but is rare in patients with venous thrombosis at other locations or with arterial thrombosis.
CONCLUSION: Routine testing for JAK2V617F is not currently recommended for patients with unexplained thromboses, except for those with splanchnic vein thrombosis. In patients with cerebral vein thrombosis, the value of testing for JAK2V617F mutation is yet to be established.
S G Xavier; T Gadelha; S M Rezende; I R Zalcberg; N Spector
Publication Detail:
Type:  Journal Article     Date:  2010-12-01
Journal Detail:
Title:  International journal of laboratory hematology     Volume:  33     ISSN:  1751-553X     ISO Abbreviation:  Int J Lab Hematol     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101300213     Medline TA:  Int J Lab Hematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  117-24     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
Department of Medical Propedeutics, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Design and NMR studies of cyclic peptides targeting the N-terminal domain of the protein tyrosine ph...
Next Document:  Heparin-induced thrombocytopenia: evaluation of IgG and IgGAM ELISA assays.