Document Detail


JAK2 V617F mutation is associated with 5q- syndrome in Chinese.
MedLine Citation:
PMID:  19562618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
JAK2 V617F mutation is mostly seen in BCR-ABLI negative myeloproliferative neoplasms. Among other myeloid neoplasms, it occurs with remarkably high frequency in refractory anemia with ring sideroblasts associated with marked thrombocytosis, a group of myeloid neoplasms with both dysplastic and proliferative features. It has also been reported in occasional cases of myelodysplastic syndrome with isolated del(5q), often with a diagnosis of refractory cytopenia with multilineage dysplasia. We performed a retrospective analysis of JAK2 V617F mutation in Chinese patients with myeloid neoplasms and isolated del(5q), and were able to demonstrate the frequent occurrence of JAK2 V617F mutation in 5q- syndrome.
Authors:
K F Wong; W S Wong; Lisa L P Siu; T C Lau; N P Chan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  50     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-11-20     Completed Date:  2010-03-09     Revised Date:  2012-06-05    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  England    
Other Details:
Languages:  eng     Pagination:  1333-5     Citation Subset:  IM    
Affiliation:
Department of Pathology, Queen Elizabeth Hospital, Hong Kong SAR, China. kfwong@ha.org.hk
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Anemia, Refractory, with Excess of Blasts / enzymology,  genetics
Chromosome Deletion*
Chromosomes, Human, Pair 5 / genetics*
Codon / genetics
Disease Progression
Female
Hong Kong / epidemiology
Humans
Janus Kinase 2 / genetics*
Karyotyping
Leukemia, Myeloid, Acute / enzymology,  genetics
Middle Aged
Myelodysplastic Syndromes / enzymology,  genetics*
Point Mutation*
Retrospective Studies
Syndrome
Chemical
Reg. No./Substance:
0/Codon; EC 2.7.10.1/Janus Kinase 2; EC 2.7.10.2/JAK2 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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