| JAK2 V617F mutation is associated with 5q- syndrome in Chinese. | |
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MedLine Citation:
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PMID: 19562618 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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JAK2 V617F mutation is mostly seen in BCR-ABLI negative myeloproliferative neoplasms. Among other myeloid neoplasms, it occurs with remarkably high frequency in refractory anemia with ring sideroblasts associated with marked thrombocytosis, a group of myeloid neoplasms with both dysplastic and proliferative features. It has also been reported in occasional cases of myelodysplastic syndrome with isolated del(5q), often with a diagnosis of refractory cytopenia with multilineage dysplasia. We performed a retrospective analysis of JAK2 V617F mutation in Chinese patients with myeloid neoplasms and isolated del(5q), and were able to demonstrate the frequent occurrence of JAK2 V617F mutation in 5q- syndrome. |
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Authors:
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K F Wong; W S Wong; Lisa L P Siu; T C Lau; N P Chan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Leukemia & lymphoma Volume: 50 ISSN: 1029-2403 ISO Abbreviation: Leuk. Lymphoma Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-11-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007422 Medline TA: Leuk Lymphoma Country: England |
Other Details:
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Languages: eng Pagination: 1333-5 Citation Subset: IM |
Affiliation:
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Department of Pathology, Queen Elizabeth Hospital, Hong Kong SAR, China. kfwong@ha.org.hk |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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