Document Detail

'J-shaped' relationship between drinking during pregnancy and birth weight: reanalysis of prospective epidemiological data.
MedLine Citation:
PMID:  7545989     Owner:  NLM     Status:  MEDLINE    
Worldwide epidemiological studies on the effects of drinking during pregnancy on birth weight and prematurity were surveyed. Far more studies have reported no significant effects on birth weight than have reported significant decreases. Statistical analyses of the means from the prospective studies in this area indicated that both maternal smoking and alcohol consumption during gestation are associated with a significant decrease in birth weight. The effect of smoking is three times greater than the effect of alcohol. When the data were stratified by smoking status, maternal alcohol consumption did not have a significant effect on birth weight for non-smokers, but among smokers there was a significant linear trend with a threshold for decreased birth weight at about an average of two drinks per day. There was also a significant pattern of increased birth weight associated with low levels of alcohol consumption, suggesting an inverted 'J-shaped' function between drinking during pregnancy and birth weight.
E L Abel; J H Hannigan
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Alcohol and alcoholism (Oxford, Oxfordshire)     Volume:  30     ISSN:  0735-0414     ISO Abbreviation:  Alcohol Alcohol.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-11-20     Completed Date:  1995-11-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8310684     Medline TA:  Alcohol Alcohol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  345-55     Citation Subset:  IM    
Department of Obstetrics/Gynecology, C.S. Mott Center for Human Growth and Development, Wayne State University, Detroit, MI 48201, USA.
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MeSH Terms
Alcohol Drinking / adverse effects*
Birth Weight / drug effects*
Cross-Cultural Comparison
Data Interpretation, Statistical
Dose-Response Relationship, Drug
Fetal Alcohol Syndrome / diagnosis,  epidemiology*
Gestational Age
Infant, Newborn
Prospective Studies
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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