| The J-Point Phenomenon in Aggressive Therapy of Hypertension: New Insights. | |
| | |
MedLine Citation:
|
PMID: 22396196 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
In the era of aggressive control of cardiovascular risk factors such as hypertension, the mantra of "lower is better" has taken a strong foothold. Although there is clear epidemiologic evidence that lower blood pressure improves specific organ-related outcomes, this rule does not apply to all patients and definitely not all target organs. The concept of J-curve or adverse outcomes at lower blood pressure has been proposed for more than three decades but has recently come under increasing scrutiny. Specifically, a relationship between adverse cardiovascular outcomes and low diastolic blood pressure has been observed in multiple clinical trials. In this article we review the advances in understanding of the J-curve phenomenon and include a discussion on specific populations that might be at higher risk due to the J-curve relationship. |
| | |
Authors:
|
Gurusher S Panjrath; Sameer Chaudhari; Franz H Messerli |
Related Documents
:
|
8729056 - A brief period of retrograde hyperthermic perfusion enhances myocardial protection from... 11321436 - In vivo microvascular actions of artemisia vulgaris l. in a model of ischemia-reperfusi... 8041176 - Cardioplegia and vascular injury. dissociation of the effects of ischemia from those of... 18334546 - Ischaemic postconditioning protects isolated mouse hearts against ischaemia/reperfusion... 6342596 - Evaluation of a reverse gradient garment for prevention of bed-rest deconditioning. 21558266 - Morphological selection and the evaluation of potential tradeoffs between escape from p... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-3-8 |
Journal Detail:
|
Title: Current atherosclerosis reports Volume: - ISSN: 1534-6242 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-3-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100897685 Medline TA: Curr Atheroscler Rep Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
The Johns Hopkins Hospital, Carnegie 568, (Cardiology), 600 North Wolfe Street, Baltimore, MD, 21287, USA, gpanjra1@jhmi.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Maternal fatty acid status during pregnancy and risk of type 1 diabetes in the offspring.
Next Document: Runt-related transcription factor 2 (RUNX2) in human colon carcinoma: A potent prognostic factor ass...