Document Detail


The "J curve" problem revisited: old and new findings.
MedLine Citation:
PMID:  20524090     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
This paper critically addresses the issue of the "J-curve" paradox--the finding described in studies performed about 30 years ago indicating that treatment-induced systolic blood pressure values below 120 or 125 mm Hg and diastolic blood pressure values below 75 mm Hg are characterized by an increase, rather than a reduction, in the incidence of coronary events. This paper focuses on four major subjects: 1) the benefits of a lower blood pressure target during treatment; 2) the historical background of the "J-curve" phenomenon; 3) the evidence collected in recent clinical trials regarding the existence of a "J-curve" in treated hypertensive patients; and 4) the recent recommendations by the Task Force Committee of the European Society of Hypertension on blood pressure goals to be achieved during treatment.
Authors:
Guido Grassi; Fosca Quarti-Trevano; Raffaella Dell'Oro; Giuseppe Mancia
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current hypertension reports     Volume:  12     ISSN:  1534-3111     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  290-5     Citation Subset:  IM    
Affiliation:
Clinica Medica, Ospedale S. Gerardo dei Tintori, Via Pergolesi 33, 20052, Monza, Milan, Italy. guido.grassi@unimib.it
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