| Ixodid tick salivary gland products target host wound healing growth factors. | |
| | |
MedLine Citation:
|
PMID: 20934428 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
For successful blood-feeding, ticks must confront the host immune system comprising many cells and signaling molecules, mainly cytokines and growth factors. These factors bind to specific receptors on the cell membranes, thereby initiating a signaling cascade that leads to distinct cellular activities. Ticks are able to manipulate host immune responses via molecules secreted from their salivary glands. Saliva of ixodid ticks contains factors binding important cytokines and their subgroup, chemokines. Here we demonstrate that constituents of tick salivary gland extract (SGE) also appear to bind growth factors: transforming growth factor beta (TGF-β1), platelet-derived growth factor (PDGF), fibroblast growth factor (FGF-2), and hepatocyte growth factor (HGF), depending on tick species. SGE derived from Amblyommavariegatum reacted with TGF-β1, PDGF, FGF-2 and HGF; Dermacentorreticulatus and Rhipicephalusappendiculatus with TGF-β1, FGF-2 and HGF; and Ixodes ricinus and Ixodesscapularis with PDGF. SGE from the species targeting PDGF (A. variegatum and I. ricinus) also inhibited cell proliferation in vitro and induced a change in morphology of different cell lines. These effects correlated with disruption of the actin cytoskeleton. Such effects were not observed with SGE of the two species that did not target PDGF. Targeting of wound healing growth factors appears to be yet another strategy ixodid ticks adopt for suppression of inflammation and successful haematophagy. |
| | |
Authors:
|
Valeria Hajnická; Iveta Vančová-Štibrániová; Mirko Slovák; Pavlína Kocáková; Patricia A Nuttall |
Related Documents
:
|
18714538 - Activation of basophils by stem cell factor: comparison with insulin-like growth factor-i. 19483748 - Twist: a new link from hypoxia to fibrosis. 1717968 - Monokines in growth and development. 1372488 - Biological activities and potential therapeutic uses of steel factor. a new growth fact... 9681918 - Deleterious network hypothesis of apoptosis. 8830798 - Glycated serum albumin induces chemokine gene expression in human retinal pigment epith... |
Publication Detail:
|
Type: Journal Article Date: 2010-10-08 |
Journal Detail:
|
Title: International journal for parasitology Volume: 41 ISSN: 1879-0135 ISO Abbreviation: Int. J. Parasitol. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0314024 Medline TA: Int J Parasitol Country: England |
Other Details:
|
Languages: eng Pagination: 213-23 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
|
Institute of Virology, Slovak Academy of Sciences, 845 05 Bratislava, Slovakia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A genetic linkage map for the apicomplexan protozoan parasite Eimeria maxima and comparison with Eim...
Next Document: Modeling major histocompatibility complex binding by nonparametric averaging of multiple predictors ...