| Ixodes holocyclus: kinetics of cutaneous basophil responses in naive, and actively and passively sensitized guinea pigs. | |
| | |
MedLine Citation:
|
PMID: 6692883 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In guinea pigs, macroscopic cutaneous reactions to initial (primary) Ixodes holocyclus feeding were first apparent at 96 hr post-tick attachment, peaked at 7 days (5 mm), and were gone by Day 14. Microscopic analyses of these primary tick feeding sites at 12, 24, 48, 72, and 96 hr post-attachment revealed the dominance mononuclear cells (63-94% of the infiltrate) at all times. Neutrophil levels were high initially (34% of the infiltrate), but quickly subsided to 6-15% of the cellular response. Eosinophils were essentially absent from primary sites, comprising only 1-3% of the infiltrate. Basophils were absent initially, but accumulated in small but significant numbers (12% of the infiltrate) at the epidermal-dermal border by 96 hr post-tick attachment, 3 days prior to maximum erythematous skin reactions. In sensitized and challenged (secondary) animals, erythematous reactions in response to secondary tick feeding were apparent as early as 18 hr post-tick attachment with peak responses at 48 hr (3-4 mm). Cutaneous leukocyte responses to challenge feedings were quantitated at 12, 24, 48, and 72 hr post-tick attachment and consisted initially (12-24 hr) of a strong mononuclear cell response (72-79% of the infiltrate) that was replaced by a dominant basophil response at 48 and 72 hr. Strong cutaneous basophil responses coincided with a significant level of tick rejection. Eosinophils and neutrophils were virtually absent from these secondary responses.(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
S J Brown; B G Bagnall; P W Askenase |
Related Documents
:
|
7686793 - Isolation and characterization of tn5-induced mutants of pseudomonas paucimobilis ut26 ... 1493883 - Factors affecting the results of t-2 mycotoxin elisa assay. 22131553 - Susceptibility to overeating affects the impact of savory or sweet drinks on satiation,... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Experimental parasitology Volume: 57 ISSN: 0014-4894 ISO Abbreviation: Exp. Parasitol. Publication Date: 1984 Feb |
Date Detail:
|
Created Date: 1984-03-14 Completed Date: 1984-03-14 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370713 Medline TA: Exp Parasitol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 40-7 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Basophils / immunology* Eosinophils Feeding Behavior Guinea Pigs Immunity, Active Immunization* Immunization, Passive* Kinetics Leukocyte Count Neutrophils Skin / immunology* Tick Infestations / immunology* Ticks / immunology*, physiology |
| Grant Support | |
ID/Acronym/Agency:
|
AI-12211/AI/NIAID NIH HHS; AI-17555/AI/NIAID NIH HHS; AI-19657/AI/NIAID NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ascaris lumbricoides and Ascaridia galli: biogenic amines in adults and developmental stages.
Next Document: Eimeria tenella, E. necatrix, E. acervulina, and E. maxima: anticoccidial activity of 1,6-dihydro-6-...