Document Detail


Ixodes dammini: salivary anaphylatoxin inactivating activity.
MedLine Citation:
PMID:  3743719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Saliva of the tick, Ixodes dammini, antagonizes anaphylatoxin, abolishing both the effects of anaphylatoxin on guinea pig ileum preparations regularly stimulated with histamine and the local edema caused by intradermal injection of anaphylatoxin into guinea pigs. Saliva of these ticks, however, did not modify polymorphonuclear leukocyte aggregation induced by anaphylatoxin. Bradykinin and lysil-bradykinin were inactivated, but angiotensin I, angiotensin II, and substance P were not affected. Amino acids were released rapidly following incubation of saliva with bradykinin, but slowly from des-arg-9-bradykinin. These results suggest the presence of a salivary carboxypeptidase with specificity for terminal basic amino acids. Such activity may inactivate anaphylatoxin and bradykinin at the site of tick attachment.
Authors:
J M Ribeiro; A Spielman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental parasitology     Volume:  62     ISSN:  0014-4894     ISO Abbreviation:  Exp. Parasitol.     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1986-10-15     Completed Date:  1986-10-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370713     Medline TA:  Exp Parasitol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  292-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anaphylatoxins / antagonists & inhibitors*
Animals
Biological Assay
Bradykinin / antagonists & inhibitors,  metabolism
Carboxypeptidases / metabolism*
Cell Aggregation
Edema / chemically induced
Guinea Pigs
Ileum / drug effects
Neutrophils / physiology
Peptides / antagonists & inhibitors*
Rats
Saliva / enzymology
Ticks / enzymology*
Grant Support
ID/Acronym/Agency:
AI-15886/AI/NIAID NIH HHS; AI-18694/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Anaphylatoxins; 0/Peptides; 58-82-2/Bradykinin; EC 3.4.-/Carboxypeptidases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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