| Ixodes dammini: salivary anaphylatoxin inactivating activity. | |
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MedLine Citation:
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PMID: 3743719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Saliva of the tick, Ixodes dammini, antagonizes anaphylatoxin, abolishing both the effects of anaphylatoxin on guinea pig ileum preparations regularly stimulated with histamine and the local edema caused by intradermal injection of anaphylatoxin into guinea pigs. Saliva of these ticks, however, did not modify polymorphonuclear leukocyte aggregation induced by anaphylatoxin. Bradykinin and lysil-bradykinin were inactivated, but angiotensin I, angiotensin II, and substance P were not affected. Amino acids were released rapidly following incubation of saliva with bradykinin, but slowly from des-arg-9-bradykinin. These results suggest the presence of a salivary carboxypeptidase with specificity for terminal basic amino acids. Such activity may inactivate anaphylatoxin and bradykinin at the site of tick attachment. |
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Authors:
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J M Ribeiro; A Spielman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Experimental parasitology Volume: 62 ISSN: 0014-4894 ISO Abbreviation: Exp. Parasitol. Publication Date: 1986 Oct |
Date Detail:
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Created Date: 1986-10-15 Completed Date: 1986-10-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370713 Medline TA: Exp Parasitol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 292-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anaphylatoxins
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antagonists & inhibitors* Animals Biological Assay Bradykinin / antagonists & inhibitors, metabolism Carboxypeptidases / metabolism* Cell Aggregation Edema / chemically induced Guinea Pigs Ileum / drug effects Neutrophils / physiology Peptides / antagonists & inhibitors* Rats Saliva / enzymology Ticks / enzymology* |
| Grant Support | |
ID/Acronym/Agency:
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AI-15886/AI/NIAID NIH HHS; AI-18694/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anaphylatoxins; 0/Peptides; 58-82-2/Bradykinin; EC 3.4.-/Carboxypeptidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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