| Ivermectin is better than benzyl benzoate for childhood scabies in developing countries. | |
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MedLine Citation:
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PMID: 12174005 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare single dose oral ivermectin with topical benzyl benzoate for the treatment of paediatric scabies. METHODS: An observer-blinded randomized controlled trial was undertaken at Vila Central Hospital, Vanuatu. One hundred and ten children aged from 6 months to 14 years were randomized to receive either ivermectin 200 micro g/kg orally or 10% benzyl benzoate topically. Follow up was at 3 weeks post-treatment. Primary outcome measures were the number of scabies lesions, the itch visual analogue score and nocturnal itch. Secondary outcome measures were the skin's reaction to treatment, the passage of worms in stool and other side effects. RESULTS: Eighty patients completed the study protocol. There was no significant difference between the two treatments; both produced a significant decrease in the number of scabies lesions seen at follow up. Ivermectin cured 24 out of 43 patients (56%), and benzyl benzoate 19 out of 37 patients (51%) at 3 weeks post-treatment. No serious side effects were noted with either treatment, but benzyl benzoate was more likely to produce local skin reactions (P = 0.004, OR 6.4, 95% CI 1.6-25.0) CONCLUSIONS: Ivermectin is cheap and effective in the treatment of paediatric scabies. Ivermectin has minimal observed toxicity and has the additional beneficial effects of antiparasitic action in onchocerciasis, filariasis and strongyloidiasis. Ivermectin is better than benzyl benzoate for the treatment of paediatric scabies in developing countries. |
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Authors:
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P A Brooks; R F Grace |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of paediatrics and child health Volume: 38 ISSN: 1034-4810 ISO Abbreviation: J Paediatr Child Health Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-08-13 Completed Date: 2002-10-16 Revised Date: 2007-09-24 |
Medline Journal Info:
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Nlm Unique ID: 9005421 Medline TA: J Paediatr Child Health Country: Australia |
Other Details:
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Languages: eng Pagination: 401-4 Citation Subset: IM |
Affiliation:
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Outpatients Department, Vila Central Hospital, Port Vila, Vanuatu. pdbrooks@netscape.net.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Benzoates / adverse effects, economics, therapeutic use* Child Child, Preschool Cost-Benefit Analysis Developing Countries Double-Blind Method Humans Infant Insecticides / adverse effects, economics, therapeutic use* Ivermectin / adverse effects, economics, therapeutic use* Scabies / drug therapy* Vanuatu |
| Chemical | |
Reg. No./Substance:
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0/Benzoates; 0/Insecticides; 120-51-4/benzyl benzoate; 70288-86-7/Ivermectin |
| Comments/Corrections | |
Comment In:
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J Paediatr Child Health. 2003 Jul;39(5):392-3
[PMID:
12887676
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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