Document Detail


Ivermectin against larval stages of Dirofilaria repens in dogs.
MedLine Citation:
PMID:  2486997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The prophylactic efficacy of ivermectin against Dirofilaria repens infections in dogs was investigated. A first trial was carried out on 15 dogs exposed to four inoculations of L3 larvae at 15-day intervals and treated, in groups of five, with 0, 6 or 12 micrograms/kg body weight of ivermectin given per os 30 and 60 days after the first inoculation. Necropsy, performed about 9 months later, revealed that worm burdens were reduced by 86.6 and 92.8% for the 6 and 12 micrograms/kg dose levels, respectively. In a second trial with an otherwise identical protocol, a dose rate of 24 micrograms/kg of ivermectin was tested in 12 dogs. Only one of the six treated dogs was found worm free at necropsy. The worm burden was reduced by 87.9% in treated animals as opposed to controls. A lengthening of the prepatent periods, which might be considered dose related, was apparent in all treated groups. Ivermectin was not completely effective in preventing establishment of experimental infections with D. repens in dogs.
Authors:
G Cancrini; P Tassi; M Coluzzi
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Parassitologia     Volume:  31     ISSN:  0048-2951     ISO Abbreviation:  Parassitologia     Publication Date:    1989 Aug-Dec
Date Detail:
Created Date:  1991-03-01     Completed Date:  1991-03-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413724     Medline TA:  Parassitologia     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  177-82     Citation Subset:  IM    
Affiliation:
Institute of Parasitology, University of Rome La Sapienza.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dirofilaria / drug effects,  growth & development,  isolation & purification
Dirofilariasis / drug therapy,  veterinary*
Dog Diseases / drug therapy*
Dogs / parasitology
Female
Ivermectin / administration & dosage,  therapeutic use*
Male
Microfilaria / drug effects
Chemical
Reg. No./Substance:
70288-86-7/Ivermectin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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