| Ivermectin acts as a posteclosion nymphicide by reducing blood feeding of human head lice (Anoplura: Pediculidae) that hatched from treated eggs. | |
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MedLine Citation:
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PMID: 22238876 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The 0.5% ivermectin topical cream formulation was not directly ovicidal to treated eggs of head lice, as hatchability was not decreased. Nevertheless, the percent of hatched lice from treated eggs that took a blood meal significantly decreased (80-95%) compared with lice that hatched from untreated eggs and all treated lice died within 48 h of hatching, including those that fed. Dilutions of ivermectin formulation of 0.15 and 0.2 microg/ml, which were topically applied to 0-8 d old eggs, were not lethal to lice at 24 h posteclosion. However, 9 and 16% less lice fed when hatched from these treated eggs, respectively. Total [3H] inulin ingested by untreated first instars significantly increased over a 48 h feeding interval but was significantly less in instars that hatched from eggs receiving the 0.15 (36% less) and 0.2 (55% less) microg/ml ivermectin treatments compared with placebo. The reduced feeding that occurred after the 0.15 and 0.2 microg/ml ivermectin treatments occurred in the absence of mortality and suggests a unique mode of action of ivermectin on feeding that is separate from the mode of action of ivermectin leading to mortality. Failure of hatched instars to take a blood meal after egg treatments with formulated ivermectin is likely responsible for its action as a posteclosion nymphicide. |
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Authors:
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Joseph P Strycharz; Noah M Berge; Anna-Maria Alves; J Marshall Clark |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of medical entomology Volume: 48 ISSN: 0022-2585 ISO Abbreviation: J. Med. Entomol. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2012-01-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375400 Medline TA: J Med Entomol Country: United States |
Other Details:
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Languages: eng Pagination: 1174-82 Citation Subset: IM |
Affiliation:
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Department of Veterinary and Animal Science, Morrill 1, N311B, 639 N. Pleasant Street, University of Massachusetts, Amherst, MA 01003, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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5 R01 AI045062-06/AI/NIAID NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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