| Ivabradine for the treatment of stable angina pectoris in octogenarians. | |
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MedLine Citation:
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PMID: 20821016 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: In patients >80 years (octogenarians), there is an increased incidence of bradycardia due to age-related alteration of the sinus node, AV node, and the conduction system. Therefore, the treatment of angina pectoris with beta-blockers may be limited by bradycardia. The REDUCTION multicenter study evaluated the efficacy of ivabradine in stable angina pectoris in everyday practice. This subgroup analysis evaluated the efficacy and safety of ivabradine in octogenarians. METHODS: A total of 4,954 patients were included in the REDUCTION study for treatment of stable angina pectoris. This group included 382 octogenarians (mean age 83 ± 2.9 years) who were followed up over 4 months. Patients were treated with ivabradine in flexible doses (2.5, 5, or 7.5 mg bid). Heart rate (HR), angina pectoris attacks, nitrate consumption, overall efficacy, and tolerance were evaluated. RESULTS: After 4 months of treatment with ivabradine, HR was reduced by 12.0 ± 12.0 bpm from 83.0 ± 15.4 to 71.0 ± 10.1 bpm (p < 0.0001). Angina pectoris attacks were reduced from 3.0 ± 4.6 to 0.8 ± 1.8 per week (p < 0.0001). Consumption of nitrates decreased from 4.2 ± 5.1 to 1.2 ± 2.7 (p < 0.0001). Four patients reported suspected adverse drug reactions. In one patient a syncope occurred. There was no symptomatic bradycardia reported. Efficacy and tolerance were assessed as 'very good/good' for 95 and 99%. CONCLUSIONS: The results demonstrate that ivabradine efficiently reduces HR, number of angina attacks, and nitrate consumption in octogenarian patients. The treatment was safe and well tolerated without relevant bradycardia. |
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Authors:
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Ralf Koester; Jan Kaehler; Thomas Meinertz |
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Publication Detail:
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Type: Journal Article Date: 2010-09-06 |
Journal Detail:
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Title: Clinical research in cardiology : official journal of the German Cardiac Society Volume: 100 ISSN: 1861-0692 ISO Abbreviation: Clin Res Cardiol Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101264123 Medline TA: Clin Res Cardiol Country: Germany |
Other Details:
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Languages: eng Pagination: 121-8 Citation Subset: IM |
Affiliation:
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Clinic for General and Interventional Cardiology, University Heart Center Hamburg, Martinistrasse 52, 20246, Hamburg, Germany, rkoester@uke.uni-hamburg.de. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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