Document Detail


Ivabradine, coronary heart disease, and heart failure: time for reappraisal.
MedLine Citation:
PMID:  25301354     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Ivabradine is generally considered to be a safe drug with well-established and substantial benefits. Nevertheless, recently published results from the SIGNIFY trial suggest that ivabradine has rather inconsistent effects on cardiovascular outcomes. In addition, careful examination of all available data from ivabradine trials reveals signals of harm that have not yet been appropriately addressed, including a markedly increased incidence of atrial fibrillation and increased risk of cardiovascular events in patients with heart rates below 70 bpm. These concerns warrant consideration, since they could have implications for the future use of ivabradine.
Authors:
Tomáš Stulc; Richard Ceška
Related Documents :
25398044 - Recent evolutions in pediatric and congenital echocardiography.
16407474 - Effects of mechanosensitive ion channels on ventricular electrophysiology: experimental...
25150984 - Anti-arrhythmic effect of diosgenin in reperfusion-induced myocardial injury in a rat m...
25388894 - Beating heart myocardial revascularisation of a sudden cardiac death survivor with spon...
25419414 - Atpase may play a critical role in disturbance of energy metabolism in congestive heart...
2929434 - Severity of coronary artery disease among blacks with acute myocardial infarction.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current atherosclerosis reports     Volume:  16     ISSN:  1534-6242     ISO Abbreviation:  Curr Atheroscler Rep     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897685     Medline TA:  Curr Atheroscler Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  463     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Endovascular versus medical therapy for atherosclerotic renovascular disease.
Next Document:  Factorial validity of an abbreviated Neighborhood Environment Walkability Scale for seniors in the N...