| I.v. ketoprofen for analgesia after tonsillectomy: comparison of pre- and post-operative administration. | |
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MedLine Citation:
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PMID: 11573528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have evaluated the safety and efficacy of ketoprofen during tonsillectomy in 106 adults receiving standardized anaesthesia. Forty-one patients received ketoprofen 0.5 mg kg(-1) at induction ('pre' ketoprofen group) and 40 patients after surgery ('post' ketoprofen group), in both cases followed by a continuous ketoprofen infusion of 3 mg kg(-1) over 24 h; 25 patients received normal saline (placebo group). Oxycodone was used for rescue analgesia. Patients in the ketoprofen groups experienced less pain than those in the placebo group. There was no difference between the study groups in the proportion of patients who were given oxycodone during the first 4 h after surgery. However, during the next 20 h, significantly more patients in the placebo group (96%) received oxycodone compared with patients in the 'pre' ketoprofen group (66%) and the 'post' ketoprofen group (55%) (P=0.002). Patients in the placebo group received significantly more oxycodone doses than patients in the two ketoprofen groups (P=0.001). Two patients (5%) in the 'pre' ketoprofen group and one (3%) in the 'post' ketoprofen group had post-operative bleeding between 4 and 14 h. All three patients required electrocautery. |
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Authors:
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A Salonen; H Kokki; K Tuovinen |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: British journal of anaesthesia Volume: 86 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-09-27 Completed Date: 2001-10-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: England |
Other Details:
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Languages: eng Pagination: 377-81 Citation Subset: IM |
Affiliation:
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Department of Otorhinolaryngology, Kuopio University Hospital, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Analgesics, Opioid / administration & dosage Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*, therapeutic use Deglutition Disorders / prevention & control Double-Blind Method Drug Administration Schedule Female Humans Infusions, Intravenous Intraoperative Care / methods Ketoprofen / administration & dosage*, therapeutic use Male Middle Aged Oxycodone / administration & dosage Pain Measurement Pain, Postoperative / prevention & control* Postoperative Care / methods Postoperative Complications Prospective Studies Tonsillectomy* |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Anti-Inflammatory Agents, Non-Steroidal; 22071-15-4/Ketoprofen; 76-42-6/Oxycodone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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