Document Detail

I.v. ketoprofen for analgesia after tonsillectomy: comparison of pre- and post-operative administration.
MedLine Citation:
PMID:  11573528     Owner:  NLM     Status:  MEDLINE    
We have evaluated the safety and efficacy of ketoprofen during tonsillectomy in 106 adults receiving standardized anaesthesia. Forty-one patients received ketoprofen 0.5 mg kg(-1) at induction ('pre' ketoprofen group) and 40 patients after surgery ('post' ketoprofen group), in both cases followed by a continuous ketoprofen infusion of 3 mg kg(-1) over 24 h; 25 patients received normal saline (placebo group). Oxycodone was used for rescue analgesia. Patients in the ketoprofen groups experienced less pain than those in the placebo group. There was no difference between the study groups in the proportion of patients who were given oxycodone during the first 4 h after surgery. However, during the next 20 h, significantly more patients in the placebo group (96%) received oxycodone compared with patients in the 'pre' ketoprofen group (66%) and the 'post' ketoprofen group (55%) (P=0.002). Patients in the placebo group received significantly more oxycodone doses than patients in the two ketoprofen groups (P=0.001). Two patients (5%) in the 'pre' ketoprofen group and one (3%) in the 'post' ketoprofen group had post-operative bleeding between 4 and 14 h. All three patients required electrocautery.
A Salonen; H Kokki; K Tuovinen
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  86     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-09-27     Completed Date:  2001-10-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  England    
Other Details:
Languages:  eng     Pagination:  377-81     Citation Subset:  IM    
Department of Otorhinolaryngology, Kuopio University Hospital, Finland.
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MeSH Terms
Analgesics, Opioid / administration & dosage
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*,  therapeutic use
Deglutition Disorders / prevention & control
Double-Blind Method
Drug Administration Schedule
Infusions, Intravenous
Intraoperative Care / methods
Ketoprofen / administration & dosage*,  therapeutic use
Middle Aged
Oxycodone / administration & dosage
Pain Measurement
Pain, Postoperative / prevention & control*
Postoperative Care / methods
Postoperative Complications
Prospective Studies
Reg. No./Substance:
0/Analgesics, Opioid; 0/Anti-Inflammatory Agents, Non-Steroidal; 22071-15-4/Ketoprofen; 76-42-6/Oxycodone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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