| It's about time: how input timing is used and not used to create emergent properties in the auditory system. | |
| | |
MedLine Citation:
|
PMID: 21325525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The hypothesis for directional selectivity of frequency modulations (FMs) invokes a mechanism with an honored tradition in sensory neurobiology, the relative timing of excitation and inhibition. The proposal is that the timing disparity is created by asymmetrical locations of excitatory tuning and inhibitory sidebands. Thus, cells in which the inhibitory sidebands are tuned to frequencies lower than the excitatory tuning are selective for downward sweeping FMs, because frequencies first generate excitation followed by inhibition. Upward sweeping FMs, in contrast, first evoke inhibition that either leads or is coincident with the excitation and prevents discharges. Here we evaluated FM directional selectivity with in vivo whole-cell recordings from the inferior colliculus of awake bats. From the whole-cell recordings, we derived synaptic conductance waveforms evoked by downward and upward FMs. We then tested the effects of shifting inhibition relative to excitation in a model and found that latency shifts had only minor effects on EPSP amplitudes that were often <1.0 mV/ms shift. However, when the PSPs peaked close to spike threshold, even small changes in latency could cause some cells to fire more strongly to a particular FM direction and thus change its directional selectivity. Furthermore, the effect of shifting inhibition depended strongly on initial latency differences and the shapes of the conductance waveforms. We conclude that "timing" is more than latency differences between excitation and inhibition, and response selectivity depends on a complex interaction between the timing, the shapes, and magnitudes of the excitatory and inhibitory conductances and spike threshold. |
| | |
Authors:
|
Joshua X Gittelman; George D Pollak |
Related Documents
:
|
21503025 - Direct slow-light excitation in photonic crystal waveguides forming ultra-compact split... 10602305 - Synthesis and chemiluminescent decomposition of spiro[1, 2-dioxetane-3,6'-benzo(c)chrom... 20031915 - Evidence of a light-sensing role for folate in arabidopsis cryptochrome blue-light rece... 18802765 - Morphological changes in the retina in pacific ocean salmon oncorhynchus masou fry in r... 20561575 - Responses of the ear to low frequency sounds, infrasound and wind turbines. 22107285 - Qcd resummation for jet substructures. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 31 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-02-17 Completed Date: 2011-04-01 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
|
Languages: eng Pagination: 2576-83 Citation Subset: IM |
Affiliation:
|
Section of Neurobiology, Institute for Neuroscience, and Center for Perceptual Systems, Patterson Laboratories, The University of Texas at Austin, Austin, Texas 78712, USA. jxg@mail.utexas.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acoustic Stimulation
/
methods Action Potentials / physiology Animals Auditory Pathways / cytology, physiology* Biophysics / methods Chiroptera Electric Stimulation / methods Excitatory Postsynaptic Potentials / physiology Models, Neurological Neural Inhibition / physiology* Patch-Clamp Techniques Reaction Time / physiology Sensory Receptor Cells / physiology Statistics as Topic Time Perception / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
1F32DC009741/DC/NIDCD NIH HHS; DC007856/DC/NIDCD NIH HHS; F32 DC009741-01/DC/NIDCD NIH HHS; R01 DC007856-05/DC/NIDCD NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Parietal area VIP causally influences heading perception during pursuit eye movements.
Next Document: Short- and long-lasting consequences of in vivo nicotine treatment on hippocampal excitability.