| Itraconazole treatment of pulmonary aspergillosis in leukaemia patients during a nosocomial epidemic associated with indoor building renovation. | |
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MedLine Citation:
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PMID: 1668179 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During indoor building renovation a nosocomial epidemic of pulmonary aspergillosis occurred in a haematological ward, involving 10 patients with acute leukaemia undergoing intensive chemotherapy. Antifungal treatment included the combination of amphotericin B and 5-fluorocytosine during periods of granulocytopenia, followed by itraconazole after bone-marrow recovery. In five patients, lung aspergillomas disappeared completely, while significant improvement was observed in a further two patients. Itraconazole appeared to contribute significantly to the result, but the drug did not work during granulocytopenic episodes. Air analyses showed increased counts of fungal spores in ward locations with heavy traffic of patients and staff, suggesting the need to identify and avoid risk areas when placing patients undergoing intensive chemotherapy. |
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Authors:
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H Brincker; B E Christensen; K G Schmidt; M K Hornstrup |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Mycoses Volume: 34 ISSN: 0933-7407 ISO Abbreviation: Mycoses Publication Date: 1991 Sep-Oct |
Date Detail:
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Created Date: 1992-08-03 Completed Date: 1992-08-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8805008 Medline TA: Mycoses Country: GERMANY |
Other Details:
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Languages: eng Pagination: 395-400 Citation Subset: IM |
Affiliation:
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Department of Oncology, Odense University Hospital, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antifungal Agents / therapeutic use* Aspergillosis / drug therapy* Cross Infection / drug therapy Facility Design and Construction Female Humans Itraconazole Ketoconazole / analogs & derivatives*, therapeutic use Leukemia, Myeloid, Acute / complications* Lung Diseases, Fungal / drug therapy* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 65277-42-1/Ketoconazole; 84625-61-6/Itraconazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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