Document Detail

Itraconazole treatment of pulmonary aspergillosis in leukaemia patients during a nosocomial epidemic associated with indoor building renovation.
MedLine Citation:
PMID:  1668179     Owner:  NLM     Status:  MEDLINE    
During indoor building renovation a nosocomial epidemic of pulmonary aspergillosis occurred in a haematological ward, involving 10 patients with acute leukaemia undergoing intensive chemotherapy. Antifungal treatment included the combination of amphotericin B and 5-fluorocytosine during periods of granulocytopenia, followed by itraconazole after bone-marrow recovery. In five patients, lung aspergillomas disappeared completely, while significant improvement was observed in a further two patients. Itraconazole appeared to contribute significantly to the result, but the drug did not work during granulocytopenic episodes. Air analyses showed increased counts of fungal spores in ward locations with heavy traffic of patients and staff, suggesting the need to identify and avoid risk areas when placing patients undergoing intensive chemotherapy.
H Brincker; B E Christensen; K G Schmidt; M K Hornstrup
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mycoses     Volume:  34     ISSN:  0933-7407     ISO Abbreviation:  Mycoses     Publication Date:    1991 Sep-Oct
Date Detail:
Created Date:  1992-08-03     Completed Date:  1992-08-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8805008     Medline TA:  Mycoses     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  395-400     Citation Subset:  IM    
Department of Oncology, Odense University Hospital, Denmark.
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MeSH Terms
Antifungal Agents / therapeutic use*
Aspergillosis / drug therapy*
Cross Infection / drug therapy
Facility Design and Construction
Ketoconazole / analogs & derivatives*,  therapeutic use
Leukemia, Myeloid, Acute / complications*
Lung Diseases, Fungal / drug therapy*
Middle Aged
Reg. No./Substance:
0/Antifungal Agents; 65277-42-1/Ketoconazole; 84625-61-6/Itraconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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