Document Detail


Itopride and pantoprazole outcomes in diabetic gastroparesis trial (IPOD trial).
MedLine Citation:
PMID:  19370958     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The most common cause of gastroparesis is diabetes mellitus. The present study was carried out to asses the combination of itopride and pantoprazole in the treatment of diabetic gastroparesis. The study was an open label, multicentre, conducted in 743 patients with diabetic gastroparesis for a period of 3 weeks. The efficacy parameters included nausea, vomiting, early satiety, bloating, postprandial fullness, epigastric pain and regurgitation. The patients were evaluated based on the frequency and severity of symptoms and compared with the baseline scores. There were significant improvement in severity as well as the frequency of all the symptom parameters of the disease (p<0.001). The physicians' evaluation to the therapy was rated either excellent or good.
Authors:
Veena Venkatesh; K P Kulkarni
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  Journal of the Indian Medical Association     Volume:  106     ISSN:  0019-5847     ISO Abbreviation:  J Indian Med Assoc     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-04-17     Completed Date:  2009-05-07     Revised Date:  2013-06-04    
Medline Journal Info:
Nlm Unique ID:  7505608     Medline TA:  J Indian Med Assoc     Country:  India    
Other Details:
Languages:  eng     Pagination:  814-5     Citation Subset:  IM    
Affiliation:
Alkem Laboratories Limited, Mumbai.
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MeSH Terms
Descriptor/Qualifier:
2-Pyridinylmethylsulfinylbenzimidazoles / therapeutic use*
Adolescent
Adult
Aged
Benzamides / therapeutic use*
Benzyl Compounds / therapeutic use*
Diabetes Complications / complications,  diagnosis,  drug therapy*
Drug Therapy, Combination
Gastrointestinal Agents / therapeutic use*
Gastroparesis / diagnosis,  drug therapy*,  etiology
Humans
Middle Aged
Proton Pump Inhibitors / therapeutic use*
Severity of Illness Index
Treatment Outcome
Young Adult
Chemical
Reg. No./Substance:
0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Benzamides; 0/Benzyl Compounds; 0/Gastrointestinal Agents; 0/Proton Pump Inhibitors; 81BMQ80QRL/itopride; D8TST4O562/pantoprazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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