| Iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) imaging of multiple myeloma: initial clinical efficiency results. | |
| | |
MedLine Citation:
|
PMID: 22138735 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVES: To evaluate the effectiveness of the iterative decomposition of water and fat with echo asymmetric and least-squares estimation (IDEAL) MRI to quantify tumour infiltration into the lumbar vertebrae in myeloma patients without visible focal lesions. METHODS: The lumbar spine was examined with 3 T MRI in 24 patients with multiple myeloma and in 26 controls. The fat-signal fraction was calculated as the mean value from three vertebral bodies. A post hoc test was used to compare the fat-signal fraction in controls and patients with monoclonal gammopathy of undetermined significance (MGUS), asymptomatic myeloma or symptomatic myeloma. Differences were considered significant at P < 0.05. The fat-signal fraction and β(2)-microglobulin-to-albumin ratio were entered into the discriminant analysis. RESULTS: Fat-signal fractions were significantly lower in patients with symptomatic myelomas (43.9 ±19.7%, P < 0.01) than in the other three groups. Discriminant analysis showed that 22 of the 24 patients (92%) were correctly classified into symptomatic or non-symptomatic myeloma groups. CONCLUSIONS: Fat quantification using the IDEAL sequence in MRI was significantly different when comparing patients with symptomatic myeloma and those with asymptomatic myeloma. The fat-signal fraction and β(2)-microglobulin-to-albumin ratio facilitated discrimination of symptomatic myeloma from non-symptomatic myeloma in patients without focal bone lesions. KEY POINTS : • A new magnetic resonance technique (IDEAL) offers new insights in multiple myeloma. • Fat-signal fractions were lower in patients with symptomatic myelomas than in those with asymptomatic myelomas. • The β2-microglobulin-to-albumin ratio also aided discrimination of symptomatic myeloma. • The fat-signal fraction may provide information about the myeloma cell mass. |
| | |
Authors:
|
Miyuki Takasu; Chihiro Tani; Yasuko Sakoda; Miho Ishikawa; Keizo Tanitame; Shuji Date; Yuji Akiyama; Akira Sakai; Hideki Asaoku; Toshio Kajima; Kazuo Awai |
Related Documents
:
|
7724035 - Is dietary intervention effective in post-transplant hyperlipidaemia? 3508445 - Ferroxidase ii activity and serum cholesterol. 11337905 - Cytomegalovirus seropositivity and serum total cholesterol levels in young patients. 2279785 - Cholesterol in serum, liver and small intestine under different dietary compositions. 11701455 - Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors. 2610005 - Sulfate and taurine excretion in rats after l-cysteine administration. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-4 |
Journal Detail:
|
Title: European radiology Volume: - ISSN: 1432-1084 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-5 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Diagnostic Radiology, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3, Kasumi, Minamiku, Hiroshimashi, 734-8551, Japan, my-takasu@syd.odn.ne.jp. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: In vivo characterisation of soft tissue tumours by 1.5-T proton MR spectroscopy.
Next Document: The impact of chief executive officer optimism on hospital strategic decision making.