Document Detail


Iterative Asymmetric Hydroformylation/Wittig Olefination Sequence.
MedLine Citation:
PMID:  23283707     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Over and over again: Various alkenes underwent the title reaction in the presence of rhodium/bis(diazaphospholane) complexes to give γ-chiral α,β-unsaturated carbonyl products (46-96 % yield) with high enantioselectivity (90-99 % ee). Iterative sequences of the reaction lead to stereoselective CC bond formations between achiral reactants to produce product having multiple stereocenters (see scheme, acac=acetylacetonate).
Authors:
Gene W Wong; Clark R Landis
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-2
Journal Detail:
Title:  Angewandte Chemie (International ed. in English)     Volume:  -     ISSN:  1521-3773     ISO Abbreviation:  Angew. Chem. Int. Ed. Engl.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370543     Medline TA:  Angew Chem Int Ed Engl     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706 (USA) http://www.chem.wisc.edu/∼landis/
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