| Itch: role of prostaglandins. | |
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MedLine Citation:
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PMID: 4755182 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prostaglandin E(1) lowers the threshold of human skin to histamine-evoked itching. Though histamine and other mediators may produce itching by a direct action, itching in inflamed skin can also be explained by a pharmacological synergism in which low concentrations of prostaglandins, which do not themselves cause itching, potentiate itching due to histamine and possibly other agents. Alteration of threshold responses of components of inflammation to other mediators may be an important general role of prostaglandins. |
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Authors:
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M W Greaves; W McDonald-Gibson |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: British medical journal Volume: 3 ISSN: 0007-1447 ISO Abbreviation: Br Med J Publication Date: 1973 Sep |
Date Detail:
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Created Date: 1974-01-19 Completed Date: 1974-01-19 Revised Date: 2010-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0372673 Medline TA: Br Med J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 608-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Bradykinin / pharmacology Child Drug Synergism Edema / chemically induced Erythema / chemically induced Female Histamine / pharmacology Humans Inflammation / chemically induced Male Middle Aged Prostaglandins / pharmacology* Pruritus / chemically induced* Skin Tests |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins; 51-45-6/Histamine; 58-82-2/Bradykinin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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