Document Detail

The Italian study on the Mitroflow postoperative results (ISTHMUS): a 20-year, multicentre evaluation of Mitroflow pericardial bioprosthesis.
MedLine Citation:
PMID:  20621499     Owner:  NLM     Status:  In-Process    
OBJECTIVE: A multicentre experience with the Mitroflow pericardial bioprosthesis has been evaluated longitudinally over a 20-year period.
METHODS: From 1988 through 2008, 1591 patients (mean age, 75.3±6.8 years, and 60.1% female) from 12 centres had a Mitroflow in the aortic position. Concomitant coronary artery bypass was performed in 41.9% (n=666) of patients, urgency/emergency surgery in 9.5% (n=152) and replacement of degenerated prosthesis in 2.3% (n=36). Follow-up (7.447 patient-years) was 99.2% complete. Median follow-up was 61.9 months (interquartile range (IQR) 30.8-90.9 months). The study was carried out following American Association for Thoracic Surgery/Society for Thoracic Surgeons/European Association for Cardio-Thoracic Surgery (AATS/STS/EACTS) Guidelines for reporting valve morbidity and mortality.
RESULTS: The early (30-day) mortality was 6.5% (n=104). Actuarial survival rates at 10, 15 and 18 years were 53%, 34% and 27%, respectively (2.2 patient/year). Re-operation was required in 96 patients (5.9%), of whom 59 patients (3.7%) for structural valve degeneration. Actuarial freedom from prosthetic valve degeneration at 18 years was 65.5% (78% in patients>70 years) with a linearised rate of 1.4 patient/year (0.8 patient/year in patients>70 years). At 18 years, freedom from embolism was 82% (0.9 patient/year), freedom from valve endocarditis was 89% (0.6 patient/year) and freedom from bleeding episodes was 95% (0.2 patient/year), respectively.
CONCLUSIONS: This independent multicentre study indicates that the Mitroflow pericardial bioprosthesis provides favourable long-term postoperative results with a low rate of valve-related events and need of re-intervention, particularly in patients older than 70 years.
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Publication Detail:
Type:  Journal Article     Date:  2010-07-10
Journal Detail:
Title:  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery     Volume:  39     ISSN:  1873-734X     ISO Abbreviation:  Eur J Cardiothorac Surg     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804069     Medline TA:  Eur J Cardiothorac Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  18-26; discussion 26     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
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MeSH Terms
Roberto Lorusso / ; Sandro Gelsomino / ; Giuseppe De Cicco / ; Enrico Vizzardi / ; Pompilio Faggiano / ; Rocco Carella / ; Giuseppe Billè / ; Giovanni Teodori / ; Philippe Caimmi / ; Guglielmo Actis Dato / ; Riccardo Casabona / ; Luca Welter / ; Ruggiero De Paulis / ; Antonio Maria Calafiore / ; Michele Di Mauro / ; Germano Di Credico / ; Cristian Leva / ; Antonio Messina / ; Emmanuel Villa / ; Gianni Troise / ; Valentino Borghetti / ; Alessandro Pardini / ; Dante Medici / ; Andrea Sala / ; Enrico Citterio / ; Alessandro Barbone / ; Ettore Vitali / ; Giuseppe Tarelli / ; Francesco Formica / ; Giovanni Paolini /

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