| It takes two transposons to tango: transposable-element-mediated chromosomal rearrangements. | |
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MedLine Citation:
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PMID: 11050333 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transposable elements (TEs) promote various chromosomal rearrangements more efficiently, and often more specifically, than other cellular processes(1-3). One explanation of such events is homologous recombination between multiple copies of a TE present in a genome. Although this does occur, strong evidence from a number of TE systems in bacteria, plants and animals suggests that another mechanism - alternative transposition - induces a large proportion of TE-associated chromosomal rearrangements. This paper reviews evidence for alternative transposition from a number of unrelated but structurally similar TEs. The similarities between alternative transposition and V(D)J recombination are also discussed, as is the use of alternative transposition as a genetic tool. |
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Authors:
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Y H Gray |
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2155853 - Quantitative effects of p elements on hybrid dysgenesis in drosophila melanogaster. 17249083 - Controlling-element events at the shrunken locus in maize. 18770743 - Processing and staining of cell and tissue material for interphase cytogenetics. |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Trends in genetics : TIG Volume: 16 ISSN: 0168-9525 ISO Abbreviation: Trends Genet. Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2000-11-21 Completed Date: 2000-11-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8507085 Medline TA: Trends Genet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 461-8 Citation Subset: IM |
Affiliation:
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Molecular Genetics and Evolution Group, Research School of Biological Sciences, Australian National University, ACT 2601, Canberra, Australia. gray@rsbs.anu.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromosomes / genetics* DNA Nucleotidyltransferases / physiology DNA Transposable Elements / genetics* Drosophila melanogaster / genetics Humans Male Models, Genetic* Mutagenesis, Insertional* Plants / genetics Recombination, Genetic VDJ Recombinases |
| Chemical | |
Reg. No./Substance:
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0/DNA Transposable Elements; EC 2.7.7.-/DNA Nucleotidyltransferases; EC 2.7.7.-/VDJ Recombinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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