| Is it time to advance the chemoprevention of environmental carcinogenesis with microdosing trials? | |
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MedLine Citation:
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PMID: 19952364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This perspective on Jubert et al. (beginning on page [1015] in this issue of the journal) discusses the use of microdosing with environmental carcinogens to accelerate the evaluation and optimization of chemopreventive interventions. The need for chemoprevention of environmental carcinogenesis is considered, as are the structure of microdosing, or phase 0, trials, technologies required to conduct microdose studies in this context, and ethical concerns. We also reflect on what microdosing studies have taught us to date. |
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Authors:
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Thomas W Kensler; John D Groopman |
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Publication Detail:
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Type: Journal Article Date: 2009-12-01 |
Journal Detail:
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Title: Cancer prevention research (Philadelphia, Pa.) Volume: 2 ISSN: 1940-6215 ISO Abbreviation: Cancer Prev Res (Phila) Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-04 Completed Date: 2010-02-16 Revised Date: 2010-09-16 |
Medline Journal Info:
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Nlm Unique ID: 101479409 Medline TA: Cancer Prev Res (Phila) Country: United States |
Other Details:
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Languages: eng Pagination: 1003-7 Citation Subset: IM |
Affiliation:
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Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA. tkensler@jhsph.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticarcinogenic Agents / administration & dosage* Carcinogens, Environmental / adverse effects* Clinical Trials as Topic Dose-Response Relationship, Drug Humans Neoplasms / prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Anticarcinogenic Agents; 0/Carcinogens, Environmental |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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