Document Detail

Issues in stinging insect allergy immunotherapy: a review.
MedLine Citation:
PMID:  18596592     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: The treatment of insect allergy by desensitization still continues to present with some unanswered questions. This review will focus mainly on articles that have dealt with these issues in the past 2 years. RECENT FINDINGS: With the publication in 2007 of Allergen Immunotherapy: a practice parameter second update, many of the key issues were reviewed and summarized. Other recent studies deal with omalizumab pretreatment of patients with systemic mastocytosis and very severe allergic reactions to immunotherapy. It would appear that venom immunotherapy is somewhat unique compared to inhalant allergen immunotherapy in that premedication prior to rush protocols may not be necessary and that intervals of therapy may be longer than with allergen immunotherapy. The use of concomitant medications such as beta-blockers may be indicated in special situations. Angiotensin-converting enzyme inhibitors can be stopped temporarily before venom injections to prevent reactions. The issue of when to discontinue immunotherapy remains unsettled and should be individualized to patient requirements. SUMMARY: The newest revision of the Immunotherapy Parameters provides much needed information concerning successful treatment with immunotherapy of Hymenoptera-sensitive patients.
Ira Finegold
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in allergy and clinical immunology     Volume:  8     ISSN:  1473-6322     ISO Abbreviation:  Curr Opin Allergy Clin Immunol     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-03     Completed Date:  2009-06-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100936359     Medline TA:  Curr Opin Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  343-7     Citation Subset:  IM    
St Luke's-Roosevelt Hospital Center, Columbia University School of Medicine, New York City, New York 10022, USA.
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MeSH Terms
Allergens / adverse effects*,  immunology,  therapeutic use
Antibodies, Monoclonal / administration & dosage,  adverse effects
Arthropod Venoms / adverse effects,  immunology,  therapeutic use*
Desensitization, Immunologic* / adverse effects,  contraindications,  standards
Drug Administration Schedule
Drug Synergism
Hypersensitivity, Immediate / chemically induced,  immunology,  therapy*
Injections, Subcutaneous
Insect Bites and Stings / immunology*
Insect Proteins / adverse effects,  immunology
Mastocytosis, Systemic / drug therapy
Withholding Treatment
Reg. No./Substance:
0/Allergens; 0/Antibodies, Monoclonal; 0/Arthropod Venoms; 0/Insect Proteins; 0/omalizumab

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