Document Detail

Isradipine for treatment of acute hypertension after myocardial revascularization.
MedLine Citation:
PMID:  1825628     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the efficacy and duration of action of iv isradipine in the control of postoperative hypertension immediately after myocardial revascularization. DESIGN: Prospective, phase 2 trial. SETTING: Surgical ICU, university hospital. PATIENTS: Twenty-one (15 male, six female) patients, ages 49 to 75 yr (mean 65 +/- 5), undergoing elective myocardial revascularization. INTERVENTIONS: Twenty-one patients with postoperative hypertension after coronary artery bypass graft surgery received iv isradipine, a new dihydropyridine calcium-channel antagonist. Mean duration of the isradipine infusion was 96.9 +/- 29 min. Mean dose of isradipine, indexed to weight, was 16.63 +/- 6.66 micrograms/kg (n = 20). MEASUREMENTS AND MAIN RESULTS: Twenty of the 21 patients achieved satisfactory BP control. The reduction in mean arterial pressure (MAP), first noted at the 15-min point, was maximal at 1 hr when MAP decreased from 102 +/- 9 mm Hg baseline to 81 +/- 5 mm Hg (p less than .01), accompanied by a significant (p less than .01) decrease in systemic vascular resistance from 1753 +/- 339 baseline to 1180 +/- 229 dyne.sec/cm5. The CVP, pulmonary artery diastolic pressure, and pulmonary artery occlusion pressure did not change significantly. Heart rate and cardiac index increased; however, stroke volume index did not change. CONCLUSIONS: Isradipine is an acceptable agent for the treatment of hypertension in this setting.
N W Brister; R E Barnette; S A Schartel; J B McClurken; J Alpern
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Critical care medicine     Volume:  19     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-04-11     Completed Date:  1991-04-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  334-8     Citation Subset:  AIM; IM    
Department of Anesthesiology, Temple University Health Sciences Center, Philadelphia, PA 19141.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Calcium Channel Blockers / therapeutic use*
Coronary Artery Bypass
Hemodynamics / drug effects
Hypertension / drug therapy*
Middle Aged
Myocardial Revascularization*
Postoperative Complications / drug therapy*
Pyridines / therapeutic use*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Calcium Channel Blockers; 0/Pyridines; 75695-93-1/Isradipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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