| Isradipine therapy in chronic stable angina pectoris--comparison with nifedipine. | |
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MedLine Citation:
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PMID: 1832382 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Current available calcium antagonists, although useful in angina pectoris, are often poorly tolerated. We therefore compared isradipine, a new calcium antagonist, with nifedipine in 18 patients with angina. Patients sequentially received incremental doses of either isradipine (IS) 2.5-7.5 mg three times daily or nifedipine (NF) 10-30 mg three times daily for 6 weeks each, in a randomized double-blind crossover study. Both agents produced similar (P = 0.43) increases in maximum exercise duration (IS + 30%; NF + 34%) and an equivalent (P = 0.38) increase in time to onset of angina on exercise (IS + 53%; NF + 62%). Both IS and NF significantly reduced exercise-induced ST depression (-40% and -45%) to a similar degree (P = 0.48). NF significantly (P = 0.019) reduced angina attacks (-3.0 attacks.week-1; 26%) compared to IS (-0.4; 4%) whilst a similar but non-significant trend in favour of NF was also apparent in the consumption of sublingual glyceryl trinitrate (-0.1 tablets.week-1; 2% vs +1.3.week-1; 23%; P = 0.28). However, significantly (P less than 0.03) more patients experienced adverse events whilst taking NF than with IS (36 events in 16/18 (89%) v 18 in 9/18 (50%). Thus, IS and NF increased exercise tolerance and reduced exercise angina and ST depression equally well although NF use was associated with fewer anginal episodes and IS with fewer side effects. |
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Authors:
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P Currie; S Saltissi |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European heart journal Volume: 12 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1991 Jul |
Date Detail:
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Created Date: 1991-10-17 Completed Date: 1991-10-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 807-12 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Royal Liverpool Hospital, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Activities of Daily Living Adult Aged Angina Pectoris / drug therapy*, etiology, physiopathology Calcium Channel Blockers / administration & dosage, adverse effects, therapeutic use* Double-Blind Method Drug Administration Schedule Electrocardiography Exercise Test Hemodynamics Humans Isradipine Middle Aged Nifedipine / administration & dosage, adverse effects, therapeutic use* Pyridines / administration & dosage, adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 0/Pyridines; 21829-25-4/Nifedipine; 75695-93-1/Isradipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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