Document Detail


Isradipine enhancement of cerebral blood flow in abstinent cocaine abusers with and without chronic perfusion deficits.
MedLine Citation:
PMID:  12202012     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nine cocaine abusers with cerebral blood flow (CBF) deficits (hypo-perfused areas) on HMPAO SPECT scans were compared to six without these deficits after six doses of isradipine (5 mg TID). When comparing the scan before isradipine to that after using SPM analysis, the ratio of hypo- to hyper-fusion showed a 16% increase in the maximum Z scores and 30% fewer areas of hypo-perfusion among those cocaine abusers with deficits. These deficits may represent segmental cerebral vasospasm that was reversed by this vasodilating agent in cocaine abusers with areas of hypo-perfusion (deficits) as baseline.
Authors:
P C H Gottschalk; Thomas R Kosten
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions     Volume:  11     ISSN:  1055-0496     ISO Abbreviation:  Am J Addict     Publication Date:  2002  
Date Detail:
Created Date:  2002-08-30     Completed Date:  2002-10-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9208821     Medline TA:  Am J Addict     Country:  United States    
Other Details:
Languages:  eng     Pagination:  200-8     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Yale University School of Medicine and the VA Connecticut Healthcare System, West Haven, Conn 06516, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain / blood supply*,  drug effects*
Cerebrovascular Circulation / drug effects
Cerebrovascular Disorders / diagnosis,  drug therapy*,  etiology*
Chronic Disease
Cocaine-Related Disorders / complications*,  epidemiology
Female
Humans
Incidence
Isradipine / administration & dosage,  pharmacology*,  therapeutic use*
Male
Oximes / diagnostic use
Radiopharmaceuticals / diagnostic use
Tomography, Emission-Computed, Single-Photon*
Vasodilator Agents / administration & dosage,  pharmacology*,  therapeutic use*
Grant Support
ID/Acronym/Agency:
K05-DA0454/DA/NIDA NIH HHS; K12-DA00167/DA/NIDA NIH HHS; P50 DA-04060/DA/NIDA NIH HHS; P50-DA12764/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Oximes; 0/Radiopharmaceuticals; 0/Vasodilator Agents; 0/hexamethylpropyleneamine oxime; 75695-93-1/Isradipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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