| Isozyme pattern of fructose diphosphate aldolase during hepatocarcinogenesis induced by 2-acetylaminofluorene in rat liver. | |
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MedLine Citation:
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PMID: 170226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The biosynthesis of aldolase A and B subunits has been studied in rat liver during the administration of carcinogen AAF4. Transition from a predominance of aldolase B to A was observed during carcinogenesis in rat liver. Changes in isozymic pattern and FDP to F-1-P cleavage activity ratio were observed before histological alterations typical of hepatoma could be detected. Our data support the hypothesis of dedifferentiation during hepatocarcinogenesis which in an early stage results in switching on of the gene for aldolase A with simultaneous continuation of biosynthesis of aldolase B within single cells. |
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Authors:
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D Silber; E Checinska; J Rabczynski; M Kochman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of cancer. Journal international du cancer Volume: 16 ISSN: 0020-7136 ISO Abbreviation: Int. J. Cancer Publication Date: 1975 Oct |
Date Detail:
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Created Date: 1976-01-02 Completed Date: 1976-01-02 Revised Date: 2007-07-24 |
Medline Journal Info:
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Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: DENMARK |
Other Details:
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Languages: eng Pagination: 682-93 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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2-Acetylaminofluorene Animals Carcinoma, Hepatocellular / chemically induced, enzymology* Fructose-Bisphosphate Aldolase / biosynthesis* Isoenzymes / biosynthesis* Liver / enzymology Liver Neoplasms / chemically induced, enzymology* Neoplasms, Experimental Rats Stimulation, Chemical |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; 53-96-3/2-Acetylaminofluorene; EC 4.1.2.13/Fructose-Bisphosphate Aldolase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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