Document Detail

Isovolumetric properties of ventricles of spontaneously hypertensive rats.
MedLine Citation:
PMID:  6454351     Owner:  NLM     Status:  MEDLINE    
Isovolumetric pressure-producing properties of isolated Langendorf-perfused hypertrophied ventricles from adult spontaneously hypertensive rats (SHR) were compared with those of nonhypertrophied ventricles from adult Wistar-Kyoto rats (WKY). SHR ventricles were found to produce greater systolic pressure than WKY ventricles when subjected to similar stimulation and perfusion conditions. Correction for the differences in ventricular mass eliminated the difference between groups. Apparent diastolic pressure at high stimulus rates was higher in SHR than WKY, and SHR developed exaggerated aftercontractions following cessation of high-frequency stimulation. Refractory periods of hypertrophied ventricles determined by paired-pulse stimulation were not found to be different from nonhypertrophied ventricles, but hyperexcitable periods of SHR ventricles were significantly longer than WKY ventricles. In addition, the intrinsic ventricular rate of SHR preparations was significantly greater than that of WKY.
L J Heller
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  240     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1981 Jun 
Date Detail:
Created Date:  1981-08-27     Completed Date:  1981-08-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H927-33     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Cardiomegaly / physiopathology
Heart / physiopathology*
Heart Ventricles / physiopathology
Hypertension / physiopathology*
Myocardial Contraction
Organ Size

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