| Isovolemic hemodilution and pancreatic islet blood flow in the rat. | |
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MedLine Citation:
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PMID: 7506238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adult rats were isovolemically hemodiluted with isotonic dextran-solutions to reduce the hematocrit by approximately one third. This procedure decreased the mean arterial blood pressure but markedly increased cardiac output. The serum glucose concentration was increased, whilst the serum insulin concentration remained unchanged. The blood flow values and the vascular conductances of both the whole pancreas and the islets were reduced by 40-60% by hemodilution. However, the decrease in islet blood flow was less affected as indicated by the increase in the percentage fraction of whole pancreatic blood flow diverted through the islets (13.5 +/- 0.7% compared to 9.7 +/- 0.8%; p < 0.05). It is concluded that isovolemic hemodilution, despite a markedly increased cardiac output, decreased both whole pancreatic blood flow and islet blood flow. |
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Authors:
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M Hindlycke; L Jansson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International surgery Volume: 78 ISSN: 0020-8868 ISO Abbreviation: Int Surg Publication Date: 1993 Jul-Sep |
Date Detail:
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Created Date: 1994-02-08 Completed Date: 1994-02-08 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0043524 Medline TA: Int Surg Country: ITALY |
Other Details:
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Languages: eng Pagination: 254-6 Citation Subset: IM |
Affiliation:
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Department of Medical Cell Biology, Uppsala University, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity / drug effects* Blood Glucose / analysis, drug effects Blood Pressure / drug effects Cardiac Output / drug effects Dextrans / pharmacology* Hematocrit Hemodilution* Insulin / blood Islets of Langerhans / blood supply, drug effects*, physiology Male Pancreas / blood supply, drug effects*, physiology Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 11061-68-0/Insulin; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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