Document Detail

Isovolemic hemodilution increases retinal tissue oxygen tension.
MedLine Citation:
PMID:  8950589     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Therapeutic isovolemic hemodilution has been reported to improve blood flow and oxygen delivery. Few reliable measurements have been made, however, showing the effect of hemodilution on tissue oxygen tension. METHODS: We measured retinal oxygen tension during experimental isovolemic hemodilution in normal cats. Polarographic oxygen microelectrodes were placed in the vitreous humor within 100-200 microns of the retinal surface. RESULTS: Tissue oxygen tension increased initially during isovolemic hemodilution to a maximum approximately 50% above baseline at approximately two thirds of the original hematocrit level. Hemodilution beyond this point to lower hematocrits caused a steady decline in tissue oxygen tension. Cardiac output measured in one cat undergoing isovolemic hemodilution increased as hematocrit was lowered, but the cardiac erythrocyte flux actually decreased steadily. CONCLUSION: The observed increase in tissue oxygen tension with hemodilution appears to be explained by a lesser reduction in capillary than in systemic hematocrit, coupled with an increased capillary blood flow. The increase in tissue oxygen tension we observed could in part explain the clinically beneficial effects of hemodilution.
K A Neely; J T Ernest; T K Goldstick; R A Linsenmeier; J Moss
Related Documents :
8342929 - Tissue oxygenation and blood flow on specialized and conventional hospital beds.
17556499 - Severe hemodilutional anemia increases cerebral tissue injury following acute neurotrauma.
18403219 - Frequency-modulated electromagnetic neural stimulation enhances cutaneous microvascular...
453699 - Effect of low-level exposure to ozone on arterial oxygenation in humans.
15529 - Effect of external factors on phototaxis of chlamydomonas reinhardtii. ii. charbon diox...
8364499 - Population pharmacokinetics of theophylline. ii: intravenous infusion to patients with ...
4068749 - Granulomonocytic colony forming cells in myelofibrosis: concentrations within hepatic b...
3517359 - Chronic maternal cigarette smoking and fetal abdominal aortic blood flow in humans.
3705149 - Evaluation of a volumetric intravenous fluid infusion pump for transfusion of blood com...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie     Volume:  234     ISSN:  0721-832X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-03-03     Completed Date:  1997-03-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  688-94     Citation Subset:  IM    
Department of Ophthalmology, University of Minnesota, Minneapolis 55455, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Flow Velocity
Blood Pressure
Blood Viscosity
Cardiac Output
Hemodilution / methods*
Oxygen / physiology*
Retina / physiology*
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  New device for artificial increasing intraocular pressure.
Next Document:  Immunolocalization of basic fibroblast growth factor during wound repair in rat retina after laser p...