Document Detail

Isotropy, iSectors, and Vertical Sections in Stereology.
MedLine Citation:
PMID:  23282634     Owner:  NLM     Status:  In-Data-Review    
Stereology provides meaningful quantitative descriptions of the geometry of three-dimensional (3D) structures from measurements that are made on two-dimensional (2D) images. One important consideration when designing such studies is that both length and surface features may have preferred orientations in 3D space; that is, they may not be isotropic. To fully understand the global estimators of length L and surface area S, it is essential that one understand the problems that the inherent anisotropy in the structure of most living organisms generates when designing unbiased sampling schemes for estimating length and surface. These same issues also apply to the use of local estimators of object volume v and surface s, in that they use line and surface probes. These problems and the various solutions to them, which involve sectioning and probing tissue in particular ways, are presented in this article.
Mark J West
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Publication Detail:
Type:  Journal Article     Date:  2013-01-01
Journal Detail:
Title:  Cold Spring Harbor protocols     Volume:  2013     ISSN:  1559-6095     ISO Abbreviation:  Cold Spring Harb Protoc     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101524530     Medline TA:  Cold Spring Harb Protoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
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