Document Detail

Isotretinoin therapy for antibiotic-refractory acne in Apert's syndrome.
MedLine Citation:
PMID:  10606949     Owner:  NLM     Status:  MEDLINE    
Apert's syndrome is a congenital disorder characterized by the premature fusion of the cranial sutures and early epiphyseal closure. Severe pustular acne is a common feature. We report a case that failed to respond to conventional antibiotic treatment but resolved following isotretinoin therapy. The patient's permanent tracheostomy proved a management challenge during isotretinoin treatment. The role of androgen-sensitivity is discussed in relation to the skin and bones.
A M Downs; C A Condon; R Tan
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  24     ISSN:  0307-6938     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-02-11     Completed Date:  2000-02-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  461-3     Citation Subset:  IM    
Department of Dermatology, Bristol Royal Infirmary, Bristol, UK.
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MeSH Terms
Acne Vulgaris / drug therapy*
Acrocephalosyndactylia / complications*,  genetics
Anti-Bacterial Agents / therapeutic use
Isotretinoin / therapeutic use*
Oxytetracycline / therapeutic use
Treatment Failure
Reg. No./Substance:
0/Anti-Bacterial Agents; 4759-48-2/Isotretinoin; 79-57-2/Oxytetracycline

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