Document Detail

Isotretinoin and serum lipids: studies on fatty acid, apolipoprotein and intermediary metabolism.
MedLine Citation:
PMID:  2958078     Owner:  NLM     Status:  MEDLINE    
Thirteen patients with severe acne were treated for 16 weeks with 1.0 mg/kg/day isotretinoin. There were significant increases in serum cholesterol (P less than 0.02), triglycerides (P less than 0.02) and apolipoprotein B (P less than 0.02). No changes were found in serum apolipoprotein A-1, non-esterified fatty acids (NEFA), carnitine, lactate, pyruvate, glycerol, alanine, beta-hydroxybutyrate, glucose or insulin. We therefore found no evidence that the hyperlipidaemia of isotretinoin therapy is due to increased fluxes of NEFA from adipose tissue to the liver, although we cannot exclude the possibility that there are changes in the proportion of NEFA being esterified to triglyceride or undergoing beta-oxidation. We suggest that the hyperlipidaemia induced by isotretinoin may be due to an increase in circulating lipoprotein from increased production or impaired catabolism.
M F Laker; C Green; A K Bhuiyan; S Shuster
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  117     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-11-04     Completed Date:  1987-11-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  203-6     Citation Subset:  IM    
Department of Dermatology, University of Newcastle upon Tyne, U.K.
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MeSH Terms
Acne Vulgaris / blood,  drug therapy*
Apolipoproteins / blood
Blood Glucose / metabolism
Carnitine / blood
Fatty Acids, Nonesterified / blood
Insulin / blood
Lipids / blood*
Tretinoin / therapeutic use*
Reg. No./Substance:
0/Apolipoproteins; 0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Lipids; 11061-68-0/Insulin; 302-79-4/Tretinoin; 4759-48-2/Isotretinoin; 541-15-1/Carnitine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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