Document Detail


Isotretinoin increases skin-surface levels of neutrophil gelatinase-associated lipocalin in patients treated for severe acne.
MedLine Citation:
PMID:  21466536     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A clear-cut need exists for safe and effective alternatives to the use of isotretinoin in severe acne. Lack of data regarding the specifics of isotretinoin's mechanism of action has hampered progress in this area. Recently, the protein neutrophil gelatinase-associated lipocalin (NGAL) has been identified as a mediator of the apoptotic effect of isotretinoin on sebocytes.
OBJECTIVES: To establish further the clinical relevance of NGAL and to elucidate the factors that induce NGAL expression in sebocytes.
METHODS: Methods were developed to isolate and quantify skin-surface levels of NGAL from normal subjects and patients with acne undergoing treatment with isotretinoin.
RESULTS: Patients with acne were found to have higher skin levels of NGAL compared with normal subjects. Studies in SEB-1 sebocytes indicate that NGAL expression is increased in response to Propionibacterium acnes and interleukin (IL)-1β. In patients, isotretinoin increases NGAL levels by 2·4-fold on the skin surface and this increase precedes decreases in sebum and P. acnes counts.
CONCLUSIONS: These data support the hypothesis that NGAL is an important mediator of the early effects of isotretinoin on the sebaceous glands and provide insights into the mechanisms that regulate NGAL expression in the skin.
Authors:
K R Lumsden; A M Nelson; M C Dispenza; K L Gilliland; Z Cong; A L Zaenglein; D M Thiboutot
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of dermatology     Volume:  165     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-22     Completed Date:  2011-10-17     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  302-10     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. BJD © 2011 British Association of Dermatologists 2011.
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MeSH Terms
Descriptor/Qualifier:
Acne Vulgaris / drug therapy*,  metabolism
Acute-Phase Proteins / metabolism*
Adolescent
Adult
Cells, Cultured
Cohort Studies
Dermatologic Agents / therapeutic use*
Enzyme-Linked Immunosorbent Assay
Humans
Interleukin-1beta / pharmacology
Interleukin-8 / metabolism
Isotretinoin / therapeutic use*
Lipocalins / metabolism*
Propionibacterium acnes / isolation & purification,  metabolism
Proto-Oncogene Proteins / metabolism*
Sebaceous Glands / cytology,  metabolism
Skin / metabolism*,  microbiology
Young Adult
Grant Support
ID/Acronym/Agency:
C06RR016499/RR/NCRR NIH HHS; F31 AR054723/AR/NIAMS NIH HHS; F31 AR054723-01/AR/NIAMS NIH HHS; F31AR054723-01/AR/NIAMS NIH HHS; M01RR010732/RR/NCRR NIH HHS; R01 AR047820/AR/NIAMS NIH HHS; R01 AR047820-06A1/AR/NIAMS NIH HHS; R01AR047820/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Dermatologic Agents; 0/Interleukin-1beta; 0/Interleukin-8; 0/LCN2 protein, human; 0/Lipocalins; 0/Proto-Oncogene Proteins; EH28UP18IF/Isotretinoin
Comments/Corrections

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