| Isotretinoin increases skin-surface levels of neutrophil gelatinase-associated lipocalin in patients treated for severe acne. | |
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MedLine Citation:
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PMID: 21466536 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A clear-cut need exists for safe and effective alternatives to the use of isotretinoin in severe acne. Lack of data regarding the specifics of isotretinoin's mechanism of action has hampered progress in this area. Recently, the protein neutrophil gelatinase-associated lipocalin (NGAL) has been identified as a mediator of the apoptotic effect of isotretinoin on sebocytes. OBJECTIVES: To establish further the clinical relevance of NGAL and to elucidate the factors that induce NGAL expression in sebocytes. METHODS: Methods were developed to isolate and quantify skin-surface levels of NGAL from normal subjects and patients with acne undergoing treatment with isotretinoin. RESULTS: Patients with acne were found to have higher skin levels of NGAL compared with normal subjects. Studies in SEB-1 sebocytes indicate that NGAL expression is increased in response to Propionibacterium acnes and interleukin (IL)-1β. In patients, isotretinoin increases NGAL levels by 2·4-fold on the skin surface and this increase precedes decreases in sebum and P. acnes counts. CONCLUSIONS: These data support the hypothesis that NGAL is an important mediator of the early effects of isotretinoin on the sebaceous glands and provide insights into the mechanisms that regulate NGAL expression in the skin. |
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Authors:
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K R Lumsden; A M Nelson; M C Dispenza; K L Gilliland; Z Cong; A L Zaenglein; D M Thiboutot |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of dermatology Volume: 165 ISSN: 1365-2133 ISO Abbreviation: Br. J. Dermatol. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-22 Completed Date: 2011-10-17 Revised Date: 2012-09-25 |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: England |
Other Details:
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Languages: eng Pagination: 302-10 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. BJD © 2011 British Association of Dermatologists 2011. |
Affiliation:
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The Jake Gittlen Cancer Research Foundation, Department of Dermatology, The Pennsylvania State University College of Medicine, Hershey, PA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acne Vulgaris
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drug therapy*,
metabolism Acute-Phase Proteins / metabolism* Adolescent Adult Cells, Cultured Cohort Studies Dermatologic Agents / therapeutic use* Enzyme-Linked Immunosorbent Assay Humans Interleukin-1beta / pharmacology Interleukin-8 / metabolism Isotretinoin / therapeutic use* Lipocalins / metabolism* Propionibacterium acnes / isolation & purification, metabolism Proto-Oncogene Proteins / metabolism* Sebaceous Glands / cytology, metabolism Skin / metabolism*, microbiology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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C06RR016499/RR/NCRR NIH HHS; F31 AR054723-01/AR/NIAMS NIH HHS; F31AR054723-01/AR/NIAMS NIH HHS; M01RR010732/RR/NCRR NIH HHS; R01 AR047820-06A1/AR/NIAMS NIH HHS; R01 AR047820-10/AR/NIAMS NIH HHS; R01AR047820/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Acute-Phase Proteins; 0/Dermatologic Agents; 0/Interleukin-1beta; 0/Interleukin-8; 0/LCN2 protein, human; 0/Lipocalins; 0/Proto-Oncogene Proteins; 4759-48-2/Isotretinoin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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