| Isotretinoin Increases Skin Surface Levels of Neutrophil Gelatinase-Associated Lipocalin in Patients Treated for Severe Acne. | |
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MedLine Citation:
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PMID: 21466536 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: A clear-cut need exists for safe and effective alternatives to the use of isotretinoin in severe acne. Lack of data regarding the specifics of isotretinoin's mechanism of action has hampered progress in this area. Recently the protein neutrophil gelatinase-associated lipocalin (NGAL) has been identified as a mediator of the apoptotic effect of isotretinoin on sebocytes. The goal of this paper is to further establish the clinical relevance of NGAL and to elucidate the factors that induce NGAL expression in sebocytes. Methods/Results: Methods were developed to isolate and quantify skin surface levels of NGAL from normal subjects and acne patients undergoing treatment with isotretinoin. Acne patients were found to have higher skin levels of NGAL compared to normal subjects. Studies in SEB-1 sebocytes indicate that NGAL expression is increased in response to P. acnes and IL-1β. In patients, isotretinoin increases NGAL levels by 2.4-fold on the skin surface and this increase precedes decreases in sebum and P. acnes counts. Conclusions: These data support the hypothesis that NGAL is an important mediator of the early effects of isotretinoin on the sebaceous glands and provide insights into the mechanisms that regulate NGAL expression in the skin. |
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Authors:
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K R Lumsden; A M Nelson; M C Dispenza; K L Gilliland; Z Cong; A L Zaenglein; D M Thiboutot |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-5 |
Journal Detail:
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Title: The British journal of dermatology Volume: - ISSN: 1365-2133 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 British Association of Dermatologists. |
Affiliation:
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The Jake Gittlen Cancer Research FoundationDepartment of Dermatology, The Pennsylvania State University College of Medicine, Hershey, PA USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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