Document Detail

Isotopic ratios to detect infringements of patents or proprietary processes of pharmaceuticals: two case studies.
MedLine Citation:
PMID:  18562148     Owner:  NLM     Status:  MEDLINE    
Because of the increasing problem of drug counterfeiting and the potential danger related as well as the economic losses involved, the pharmaceutical industry and the regulatory instances are interested in the development of anti-counterfeiting and patent protection methodologies. In this paper, the evaluation of measured isotopic ratios by means of explorative chemometric techniques was performed to distinguish groups in two data sets containing samples of acetyl salicylic acid and ibuprofen, respectively. The samples in the data sets originated from different countries and manufacturers. For both compounds a clear distinction of groups of samples could be obtained. These groups could be explained based on the origin of the samples, both geographically as well as based on the manufacturer. Hypotheses were formulated concerning the synthetic pathways of the molecules and they were linked to the groups obtained with the chemometric tools.
E Deconinck; A M van Nederkassel; I Stanimirova; M Daszykowski; F Bensaid; M Lees; G J Martin; J R Desmurs; J Smeyers-Verbeke; Y Vander Heyden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-29
Journal Detail:
Title:  Journal of pharmaceutical and biomedical analysis     Volume:  48     ISSN:  0731-7085     ISO Abbreviation:  J Pharm Biomed Anal     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-26     Completed Date:  2008-11-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309336     Medline TA:  J Pharm Biomed Anal     Country:  England    
Other Details:
Languages:  eng     Pagination:  27-41     Citation Subset:  IM    
Vrije Universiteit Brussel (VUB), Department of Analytical Chemistry and Pharmaceutical Technology, Laarbeeklaan 103, B-1090 Brussels, Belgium.
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MeSH Terms
Analgesics, Non-Narcotic / analysis*,  chemical synthesis,  isolation & purification
Carbon Isotopes / analysis*
Drug Industry / economics*
Ibuprofen / analysis*,  chemical synthesis,  isolation & purification
Pharmaceutical Preparations / economics*
Principal Component Analysis
Salicylic Acid / analysis*,  chemical synthesis,  isolation & purification
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 0/Carbon Isotopes; 0/Pharmaceutical Preparations; 15687-27-1/Ibuprofen; 69-72-7/Salicylic Acid

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