| BN/CC Isosteric Compounds as Enzyme Inhibitors: N- and B-ethyl-1,2-azaborine Inhibit Ethylbenzene Hydroxylation as Non-Convertible Substrate Analogues. | |
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MedLine Citation:
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PMID: 23355270 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Good substrate gone bad! BN/CC isosterism of ethylbenzene leads to N-ethyl-1,2-azaborine and B-ethyl-1,2-azaborine. In contrast to ethylbenzene, which is the substrate for ethylbenzene dehydrogenase (EbDH), N-ethyl-1,2-azaborine (see scheme; Fc=Ferricenium tetrafluoroborate) and B-ethyl-1,2-azaborine are strong inhibitors of EbDH. Thus the changes provided by BN/CC isosterism can lead to new biochemical reactivity. |
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Authors:
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Daniel H Knack; Jonathan L Marshall; Gregory P Harlow; Agnieszka Dudzik; Maciej Szaleniec; Shih-Yuan Liu; Johann Heider |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-28 |
Journal Detail:
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Title: Angewandte Chemie (International ed. in English) Volume: - ISSN: 1521-3773 ISO Abbreviation: Angew. Chem. Int. Ed. Engl. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370543 Medline TA: Angew Chem Int Ed Engl Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Laboratory for Microbial Biochemistry, Philipps University of Marburg, 35043 Marburg (Germany). |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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