| Isosorbide dinitrate: relationship between pharmacokinetics and brachial artery hemodynamics in essential hypertension. | |
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MedLine Citation:
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PMID: 3740548 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pharmacokinetics of isosorbide dinitrate (ISDN) and brachial arterial hemodynamics have been studied in 15 patients with sustained essential hypertension. The hemodynamic study was performed by using a pulsed Doppler device enabling evaluation of the diameter of the brachial artery with an error of less than 10%. After intravenous administration until plateau concentrations were reached, the ISDN infusion was stopped in order to study the disappearance curve of the drug and the pharmacokinetic parameters. ISDN caused a significant decrease in systolic pressure, a significant increase in arterial diameter, and no change in heart rate. Brachial hemodynamics were not correlated with the plasma concentration in the steady state or the area under the disappearance curve. In contrast, the changes in arterial diameter during perfusion were significantly correlated with the apparent distribution volume, a finding that might indirectly reflect the affinity of ISDN for vascular tissues. |
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Authors:
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A M Frydman; M E Safar; A C Simon; J A Levenson; J Gaillot; E Roland |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Angiology Volume: 37 ISSN: 0003-3197 ISO Abbreviation: Angiology Publication Date: 1986 Aug |
Date Detail:
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Created Date: 1986-09-17 Completed Date: 1986-09-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 581-91 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brachial Artery / physiopathology* Female Hemodynamics / drug effects Humans Hypertension / physiopathology* Isosorbide Dinitrate / blood, metabolism* Kinetics Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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87-33-2/Isosorbide Dinitrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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