Document Detail


Isosorbide dinitrate: relationship between pharmacokinetics and brachial artery hemodynamics in essential hypertension.
MedLine Citation:
PMID:  3740548     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pharmacokinetics of isosorbide dinitrate (ISDN) and brachial arterial hemodynamics have been studied in 15 patients with sustained essential hypertension. The hemodynamic study was performed by using a pulsed Doppler device enabling evaluation of the diameter of the brachial artery with an error of less than 10%. After intravenous administration until plateau concentrations were reached, the ISDN infusion was stopped in order to study the disappearance curve of the drug and the pharmacokinetic parameters. ISDN caused a significant decrease in systolic pressure, a significant increase in arterial diameter, and no change in heart rate. Brachial hemodynamics were not correlated with the plasma concentration in the steady state or the area under the disappearance curve. In contrast, the changes in arterial diameter during perfusion were significantly correlated with the apparent distribution volume, a finding that might indirectly reflect the affinity of ISDN for vascular tissues.
Authors:
A M Frydman; M E Safar; A C Simon; J A Levenson; J Gaillot; E Roland
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Angiology     Volume:  37     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  581-91     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Brachial Artery / physiopathology*
Female
Hemodynamics / drug effects
Humans
Hypertension / physiopathology*
Isosorbide Dinitrate / blood,  metabolism*
Kinetics
Male
Middle Aged
Chemical
Reg. No./Substance:
87-33-2/Isosorbide Dinitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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