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Isoproterenol infusion and microcirculation in septic shock.
MedLine Citation:
PMID:  25436209     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: Our study primarily aimed at investigating the effect of isoproterenol infusion on tissue oxygen saturation in patients with septic shock. The secondary aim was to assess the relation between cardiac index, central venous oxygen saturation and tissue oxygen saturation.
METHODS: This retrospective study was conducted from December 2010 to March 2012. We included 14 consecutive patients with septic shock treated with isoproterenol. All patients were monitored by cardiac index and tissue oxygen saturation. From medical charts, routine hemodynamic data were extracted one hour before and six hours after the onset of isoproterenol infusion.
RESULTS: From baseline to H6, tissue oxygen saturation levels rise from 78 [72-82]% to 85 [78-88]% (p = 0.03). Isoproterenol infusion was associated with an increase of central venous oxygen saturation (from 67 [65-74]% to 84 [77-86]%, p = 0.02) and cardiac index (from 2.9 [2.7-3.1] L/min/m² to 3.9 [3.0-4.4] L/min/m², p = 0.006). Tissue oxygen saturation was correlated neither to cardiac index (p = 0.14, R(2) = 0.08) nor to central venous oxygen saturation (p = 0.19, R(2) = 0.10).
CONCLUSIONS: Use of isoproterenol was associated with an increase of tissue oxygen saturation. This increase was not correlated to cardiac index, suggesting a decoupling between macrocirculation and microcirculation.
Authors:
S Wiramus; J Textoris; R Bardin; C Vigne; C Kelway; C Martin; M Leone
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Heart, lung and vessels     Volume:  6     ISSN:  2282-8419     ISO Abbreviation:  Heart Lung Vessel     Publication Date:  2014  
Date Detail:
Created Date:  2014-12-1     Completed Date:  -     Revised Date:  2014-12-2    
Medline Journal Info:
Nlm Unique ID:  101618180     Medline TA:  Heart Lung Vessel     Country:  -    
Other Details:
Languages:  ENG     Pagination:  274-279     Citation Subset:  -    
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