Document Detail

Isoproterenol induces a ribosomal modification in the heart and the skeletal muscle of hamsters.
MedLine Citation:
PMID:  3986306     Owner:  NLM     Status:  MEDLINE    
The protein synthesis activity of heart, skeletal muscle and liver polysomes from isoprotenerol-treated and control hamsters has been compared in an in vitro non-initiating translation system. Heart and skeletal muscle polysomes from treated hamsters were less active than controls and required a higher magnesium concentration for optimal protein synthesis. These results suggest that there is a conformational modification in heart and skeletal muscle ribosomes from isoprotenerol-treated hamsters. No such change was observed with ribosomes from the liver of isoproterenol-treated hamsters.
J Noël; L Brakier-Gingras
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bioscience reports     Volume:  5     ISSN:  0144-8463     ISO Abbreviation:  Biosci. Rep.     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-05-29     Completed Date:  1985-05-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102797     Medline TA:  Biosci Rep     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  13-9     Citation Subset:  IM    
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MeSH Terms
Heart / drug effects*
Isoproterenol / pharmacology*
Muscles / drug effects*,  metabolism
Myocardium / metabolism
RNA, Messenger / metabolism
Ribosomal Proteins / biosynthesis
Ribosomes / drug effects*,  metabolism
Reg. No./Substance:
0/RNA, Messenger; 0/Ribosomal Proteins; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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