| Isoprodian and rifampicin in the treatment of leprosy: a descriptive evaluation of therapy durations in 475 Paraguayan leprosy patients. | |
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MedLine Citation:
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PMID: 2676405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In Paraguay, the National Leprosy/Tuberculosis Program is based on a combined chemotherapy with isoprodian and rifampicin. The aim of this descriptive study was to investigate the therapy durations used so far in the treatment of 475 leprosy patients and to analyze the criteria responsible for the wide-ranging differences in therapy durations. As initial criteria, the following parameters were identified to have a significant influence on the therapy duration: Patients never treated before or pretreated, clinical classification and initial bacteriological index (BI) value. During therapy, conditions like the attendance and BI decrease/year showed a significant correlation with the therapy duration. Even though the studied criteria did not allow to draw a definite conclusion with regard to an 'ideal' therapy duration, they proved to be reliable, as only 2 patients have relapsed so far. |
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Authors:
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S Pritze; A E Alvarenga; O Leguizamon; I Haubitz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chemotherapy Volume: 35 ISSN: 0009-3157 ISO Abbreviation: Chemotherapy Publication Date: 1989 |
Date Detail:
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Created Date: 1989-11-21 Completed Date: 1989-11-21 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0144731 Medline TA: Chemotherapy Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 373-82 Citation Subset: IM |
Affiliation:
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Armauer-Hansen-Institut, Würzburg, FRG. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Dapsone
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therapeutic use* Drug Combinations / therapeutic use Drug Therapy, Combination Humans Isoniazid / therapeutic use* Isonicotinic Acids / therapeutic use* Leprostatic Agents / therapeutic use* Leprosy / drug therapy* Leprosy, Borderline / drug therapy Leprosy, Lepromatous / drug therapy Leprosy, Tuberculoid / drug therapy Mycobacterium leprae / drug effects, isolation & purification Paraguay Patient Compliance Prothionamide / therapeutic use* Rifampin / therapeutic use* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 0/Isonicotinic Acids; 0/Leprostatic Agents; 13292-46-1/Rifampin; 14222-60-7/Prothionamide; 54-85-3/Isoniazid; 55015-10-6/isoprodian; 80-08-0/Dapsone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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