Document Detail

Isoprenaline-induced myocardial necrosis in dogs.
MedLine Citation:
PMID:  656315     Owner:  NLM     Status:  MEDLINE    
Subcutaneous injections of isoprenaline sulphate in dogs (1-3 mg/kg) resulted in myocardial injury. Good correlation was observed between abnormal ECG recordings, serum enzyme concentrations and myocardial lesions in the acute phase of injury. However, in cases where less extensive myocardial injury was produced due to lower doses of isoprenaline or in cases of the reparative phase of the isoprenaline-induced myocardial injury, serum enzymes were not useful indicators of the change. Similary, ECG recordings taken peripherally also did not show alteration in the reparative phase of the injury in spite of extensive myocardial lesions.
C Gopinath; J Thuring; I Zayed
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of experimental pathology     Volume:  59     ISSN:  0007-1021     ISO Abbreviation:  Br J Exp Pathol     Publication Date:  1978 Apr 
Date Detail:
Created Date:  1978-08-14     Completed Date:  1978-08-14     Revised Date:  2012-05-07    
Medline Journal Info:
Nlm Unique ID:  0372543     Medline TA:  Br J Exp Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  148-57     Citation Subset:  IM    
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MeSH Terms
Enzymes / blood
Heart Diseases / chemically induced*,  enzymology
Isoproterenol / toxicity*
Myocardium / enzymology,  pathology
Succinate Dehydrogenase / metabolism
Reg. No./Substance:
0/Enzymes; 7683-59-2/Isoproterenol; EC Dehydrogenase

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