Document Detail

Isonicotinates, nicotinates and clofibrates of N-methyl-N-(2-hydroxyethyl or 3-hydroxypropyl)--1,3,3-trimethylbicyclo [2.2.1]heptan-2-endo-amine with hypocholesterolemic and hypolipidemic activity.
MedLine Citation:
PMID:  3595837     Owner:  NLM     Status:  MEDLINE    
The synthesis of isonicotinic, nicotinic and clofibric esters (III a, b, c) and (IV a, b, c) starting from N-methyl-N-(2-hydroxyethyl or 3-hydroxypropyl)-1,3,3-trimethylbicyclo [2.2.1] heptan-2-endo-amine is described. In general these esters showed a normolipemic activity in rats; in particular, the isonicotinic ester (IV a) showed a hypocholesterolemic activity higher than that of clofibric acid.
F Bondavalli; O Bruno; P Schenone; C Vacca; R De Carlo; E Marmo
Related Documents :
12585897 - Total synthesis of (s)-(+)-citreofuran by ring closing alkyne metathesis.
17899337 - Synthesized esters of ferulic acid induce release of cytochrome c from rat testes mitoc...
956327 - Structure determination of polyunsaturated fatty acids by gas chromatography-mass spect...
19644517 - Nitro derivatives from the arctic ice bacterium salegentibacter sp. isolate t436.
9465967 - Effects of carbontetrachloride and chenodeoxycholic acid on hepatic monooxygenase syste...
19022967 - Frequency and type of seafood consumed influence plasma (n-3) fatty acid concentrations.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Il Farmaco; edizione scientifica     Volume:  42     ISSN:  0430-0920     ISO Abbreviation:  Farmaco Sci     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-08-20     Completed Date:  1987-08-20     Revised Date:  2009-06-05    
Medline Journal Info:
Nlm Unique ID:  0370716     Medline TA:  Farmaco Sci     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  251-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anticholesteremic Agents / chemical synthesis*,  pharmacology
Antilipemic Agents / chemical synthesis*,  pharmacology
Chemical Phenomena
Cholesterol / blood
Clofibrate / analogs & derivatives*,  chemical synthesis,  pharmacology
Isonicotinic Acids / chemical synthesis*,  pharmacology
Lipids / blood
Nicotinic Acids / chemical synthesis*,  pharmacology
Spectrophotometry, Infrared
Triglycerides / blood,  metabolism
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Antilipemic Agents; 0/Isonicotinic Acids; 0/Lipids; 0/Nicotinic Acids; 0/Triglycerides; 57-88-5/Cholesterol; 637-07-0/Clofibrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Preparation and analgesic activity of tetrahydroquinolines and tetrahydroisoquinolines
Next Document:  Synthesis of some 3-hydroxy-5-aminopentanoic acid derivatives.