Document Detail


Isonicotinates, nicotinates and clofibrates of N-methyl-N-(2-hydroxyethyl or 3-hydroxypropyl)--1,3,3-trimethylbicyclo [2.2.1]heptan-2-endo-amine with hypocholesterolemic and hypolipidemic activity.
MedLine Citation:
PMID:  3595837     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The synthesis of isonicotinic, nicotinic and clofibric esters (III a, b, c) and (IV a, b, c) starting from N-methyl-N-(2-hydroxyethyl or 3-hydroxypropyl)-1,3,3-trimethylbicyclo [2.2.1] heptan-2-endo-amine is described. In general these esters showed a normolipemic activity in rats; in particular, the isonicotinic ester (IV a) showed a hypocholesterolemic activity higher than that of clofibric acid.
Authors:
F Bondavalli; O Bruno; P Schenone; C Vacca; R De Carlo; E Marmo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Il Farmaco; edizione scientifica     Volume:  42     ISSN:  0430-0920     ISO Abbreviation:  Farmaco Sci     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-08-20     Completed Date:  1987-08-20     Revised Date:  2009-06-05    
Medline Journal Info:
Nlm Unique ID:  0370716     Medline TA:  Farmaco Sci     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  251-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anticholesteremic Agents / chemical synthesis*,  pharmacology
Antilipemic Agents / chemical synthesis*,  pharmacology
Chemical Phenomena
Chemistry
Cholesterol / blood
Clofibrate / analogs & derivatives*,  chemical synthesis,  pharmacology
Isonicotinic Acids / chemical synthesis*,  pharmacology
Lipids / blood
Nicotinic Acids / chemical synthesis*,  pharmacology
Rats
Spectrophotometry, Infrared
Triglycerides / blood,  metabolism
Chemical
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Antilipemic Agents; 0/Isonicotinic Acids; 0/Lipids; 0/Nicotinic Acids; 0/Triglycerides; 57-88-5/Cholesterol; 637-07-0/Clofibrate

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