Document Detail

Isoniazid prophylaxis among Alaskan Eskimos: a final report of the bethel isoniazid studies.
MedLine Citation:
PMID:  453704     Owner:  NLM     Status:  MEDLINE    
As a result of numerous trials, isoniazid prophylaxis was shown to be effective in preventing tuberculosis in many different populations and under a variety of conditions. However, the duration of the protective effect has been of some concern. In a previous report, the protective effect of isoniazid prophylaxis among Alaskan Eskimos was shown to persist through the fifteenth year after its administration. In this final report, the protective effect is shown to persist for more than 19 years. The magnitude of the effect is related to the amount of isoniazid taken. The results of the study are consistent with the hypothesis that the decrease in risk of tuberculosis produced by isoniazid preventive therapy is lifelong.
G W Comstock; C Baum; D E Snider
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  119     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1979 May 
Date Detail:
Created Date:  1979-09-01     Completed Date:  1979-09-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  827-30     Citation Subset:  AIM; IM    
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MeSH Terms
Dose-Response Relationship, Drug
Isoniazid / therapeutic use*
Tuberculosis, Pulmonary / prevention & control*
Reg. No./Substance:

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