Document Detail

Isometric handgrip training does not improve flow-mediated dilation in subjects with normal blood pressure.
MedLine Citation:
PMID:  17140398     Owner:  NLM     Status:  MEDLINE    
Isometric HG (handgrip) training lowers resting arterial BP (blood pressure), yet the mechanisms are elusive. In the present study, we investigated improved systemic endothelial function as a mechanism of arterial BP modification following isometric HG training in normotensive individuals. This study employed a within-subject repeated measures design primarily to assess improvements in BA FMD (brachial artery flow-mediated dilation; an index of endothelium-dependent vasodilation), with the non-exercising limb acting as an internal control. Eleven subjects performed four 2-min unilateral isometric HG contractions at 30% of maximal effort, three times per week for 8 weeks. Pre-, mid- and post-training resting ABP and BA FMD (exercised arm and non-exercised arm) were measured via automated brachial oscillometry and ultrasound respectively. BA FMD (normalized to the peak shear rate experienced in response to the reactive hyperaemic stimulus) remained unchanged [exercised arm, 0.029+/-0.003 to 0.026+/-0.003 to 0.029+/-0.004%/s(-1) (pre- to mid- to post-training respectively); non-exercised arm, 0.023+/-0.003 to 0.023+/-0.003 to 0.024+/-0.003%/s(-1) (pre- to mid- to post-training respectively); P=0.22]. In conclusion, improved systemic endothelial function is unlikely to be responsible for lowering arterial BP in this population.
Cheri L McGowan; Andrew S Levy; Neil McCartney; Maureen J MacDonald
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  112     ISSN:  1470-8736     ISO Abbreviation:  Clin. Sci.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-02-27     Completed Date:  2007-04-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  403-9     Citation Subset:  IM    
Department of Kinesiology, McMaster University, Hamilton, ON, Canada.
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MeSH Terms
Analysis of Variance
Blood Pressure / physiology
Brachial Artery / physiology*,  ultrasonography
Case-Control Studies
Hand Strength / physiology
Isometric Contraction / physiology*
Laser-Doppler Flowmetry
Physical Therapy Modalities*
Regional Blood Flow / physiology
Vasodilation / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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