Document Detail

Isometric handgrip exercise during cardiovascular magnetic resonance imaging: Set-up and cardiovascular effects.
MedLine Citation:
PMID:  23348933     Owner:  NLM     Status:  Publisher    
PURPOSE: To establish a suitable setup for combining isometric handgrip exercise with cardiovascular magnetic resonance (CMR) imaging and to assess cardiovascular effects. MATERIALS AND METHODS: Fifty-three healthy volunteers (31 males, mean age 45 ± 17 years) underwent handgrip exercise in a 3T scanner using a prototype handgrip system and a custom-made feedback system that displayed the force. Handgrip was sustained at 30% of the maximal contraction for 6-8 minutes. Heart rate, blood pressure (BP), and double product were determined sequentially. Stroke volume was quantified in a subgroup (n = 21) at rest and stress using phase contrast acquisitions. RESULTS: Heart rate increased significantly between rest and stress by 20 ± 13%, systolic / diastolic / mean BP by 15 ± 11% / 20 ± 18% / 17 ± 13%, double product by 37 ± 21%, and cardiac output by 27 ± 16% (each P < 0.001). Stroke volume did not significantly increase (3 ± 9%; P = 0.215). Higher age was associated with reduced increase of stroke volume (P = 0.022) and cardiac output (P < 0.001). Overweight subjects showed less increases in heart rate (P = 0.021) and cardiac output (P = 0.002). CONCLUSION: The handgrip exercise during CMR with the presented set-up leads to considerable hemodynamic changes in healthy volunteers. J. Magn. Reson. Imaging 2013;. © 2013 Wiley Periodicals, Inc.
Florian von Knobelsdorff-Brenkenhoff; Matthias A Dieringer; Katharina Fuchs; Fabian Hezel; Thoralf Niendorf; Jeanette Schulz-Menger
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  -     ISSN:  1522-2586     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
Berlin Ultrahigh Field Facility (B.U.F.F), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrueck Center for Molecular Medicine, HELIOS Klinikum Berlin Buch, Department of Cardiology and Nephrology, Berlin, Germany.
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