Document Detail

Isometric exercise in patients with chronic advanced heart failure: hemodynamic and neurohumoral evaluation.
MedLine Citation:
PMID:  3899405     Owner:  NLM     Status:  MEDLINE    
We evaluated the hemodynamic effects of isometric exercise in 53 patients with congestive heart failure (CHF) and compared them with those found in 10 normal subjects. In both groups, isometric exercise increased heart rate and blood pressure. Systemic resistance increased in patients with CHF (1862 +/- 520 vs 2126 +/- 642 dyne-sec-cm-5; p less than .001) but not in normal subjects (1359 +/- 268 vs 1380 +/- 252 dyne-sec-cm-5). Cardiac index and stroke volume index increased mildly but not significantly in the normal subjects (2.8 +/- 0.5 vs 3.1 +/- 0.7 liters/min/m2 and 46 +/- 8 vs 47 +/- 7 ml/m2) and showed a significant fall in the patients with CHF (2.1 +/- 0.6 to 1.9 +/- 0.6 liters/min/m2, p less than .01 and 23 +/- 7 vs 20 +/- 7 ml/m2, p less than .01). Mean pulmonary arterial wedge pressure increased in patients with CHF from 26 +/- 7 to 30 +/- 8 mm Hg (p less than .001). Although no significant change was found in mean value for stroke work index (21 +/- 9 vs 20 +/- 9 g-m/m2), the individual changes were variable, with marked decrease (greater than 15%) in 17 of the patients. This hemodynamic deterioration could not be predicted from resting hemodynamics, left ventricular ejection fraction, or functional classification. Isometric exercise resulted in no significant change in circulatory catecholamine levels or plasma renin concentration in our 10 normal subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
U Elkayam; A Roth; L Weber; W Hsueh; M Nanna; L Freidenberger; P A Chandraratna; S H Rahimtoola
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation     Volume:  72     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1985-11-21     Completed Date:  1985-11-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  975-81     Citation Subset:  AIM; IM    
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MeSH Terms
Catecholamines / metabolism
Epinephrine / metabolism
Heart Failure / physiopathology*
Isometric Contraction*
Middle Aged
Muscle Contraction*
Norepinephrine / metabolism
Renin / metabolism
Reg. No./Substance:
0/Catecholamines; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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